Synthesis of (-)-hygromycin A: application of Mitsunobu glycosylation and tethered aminohydroxylation.
Key points in the synthesis of (-)-hygromycin A are the tethered aminohydroxylation reaction used to prepare the aminocyclitol unit and the choice of a bulky protecting group on the sugar unit to facilitate selective Mitsunobu glycosylation and also bestow kinetic stability upon an otherwise vulnera...
| Váldodahkkit: | , , , |
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| Materiálatiipa: | Journal article |
| Giella: | English |
| Almmustuhtton: |
2009
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| Čoahkkáigeassu: | Key points in the synthesis of (-)-hygromycin A are the tethered aminohydroxylation reaction used to prepare the aminocyclitol unit and the choice of a bulky protecting group on the sugar unit to facilitate selective Mitsunobu glycosylation and also bestow kinetic stability upon an otherwise vulnerable proton. © 2009 Wiley-VCH Verlag GmbH and Co. KCaA. |
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