Analysis of potassium (K+) efflux systems (Kef) as an antibiotic target in pathogenic bacteria

Analysis of potassium (K+) efflux systems (Kef) as an antibiotic target in pathogenic bacteria

<p>Potassium (K<sup>+</sup>) efflux systems (Kef) are K<sup>+</sup>/H<sup>+</sup> antiporters found in most Gram-negative bacteria. Kef systems play a vital role in the protection of bacteria from toxic electrophiles by regulating cytoplasmic pH and conseque...

Fuld beskrivelse

Bibliografiske detaljer
Hovedforfatter:	Haslam, C
Andre forfattere:	Conway, S
Format:	Thesis
Sprog:	English
Udgivet:	2019
Fag:	Organic Chemistry Biochemistry Medicinal Chemistry Biological Chemistry Chemical Biology

Lignende værker

Development of small-molecule, peptide-mimetic, activating ligands of the potassium efflux (Kef) system
af: Bunce, HAP
Udgivet: (2021)

Anti-fungal effect of chloroform crude extract from the leaves of thottea corymbosa / Siti Zaiton Mat So 'ad, Neni Kartini Che Mohd Ramli and Aiza Harun
af: Mat So'ad, Siti Zaiton, et al.
Udgivet: (2006)

Kinetic and mechanistic studies of oxygen sensing Fe(II)/2-oxoglutarate dependent oxygenases
af: Tarhonskaya, H
Udgivet: (2014)

A potent and selective inhibitor of a histone demethylase
af: England, K
Udgivet: (2016)

Biophysical studies of oligonucleotides containing duplex stabilising modifications
af: Marafini, P
Udgivet: (2016)

LanCLs have C-glutathionylation activity with potential to trap the eliminylome
af: Lai, K, et al.
Udgivet: (2020)

An introduction to practical biochemistry /
af: 423751 Plummer, David T.
Udgivet: (1989)

Targeting the Ras superfamily via their regulatory GEF complexes
af: Gray, J
Udgivet: (2021)

Engineered α-hemolysin pores with chemically and genetically-fused functional proteins
af: Mantri, S
Udgivet: (2013)

Engineered α-hemolysin pores with chemically and genetically-fused functional proteins
af: Mantri, S
Udgivet: (2013)

Mutate & conjugate: a method for rapid in-cell validation of epigenetic targets
af: Thomas, AM
Udgivet: (2022)

Chemical tools for the study of epigenetic mechanisms
af: Lercher, L
Udgivet: (2014)

Site-specific chemical modification of antibodies for the modulation of function
af: Gunnoo, S, et al.
Udgivet: (2013)

Radical chemistry for selective modification of native residues in proteins
af: Imiolek, M
Udgivet: (2020)

Protein-ligand binding interactions of imidazolium salts with SARS CoV-2
af: Dhurairaj Satheesh, et al.
Udgivet: (2020-11-01)

The physical chemistry of membranes/
af: 299803 Starzak, Michael E.
Udgivet: (1984)

Synthesis of Mycobacterium tuberculosis ATP synthase inhibitors
af: Pattarakiat, Seankongsuk
Udgivet: (2022)

Molecular glue-mediated targeted protein degradation: A novel strategy in small-molecule drug development
af: Xueqiang Tan, et al.
Udgivet: (2024-09-01)

Synthetic phosphorylation of kinases for functional studies in vitro
af: Chooi, K
Udgivet: (2014)

Targeting thioredoxin reductase with organometallics
af: Koh, Wei Xiang
Udgivet: (2021)

Selective modification and detection of the DNA bases
af: Wallace, E
Udgivet: (2011)

The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5
af: Carter, JL
Udgivet: (2023)

Novel methods in glycosaminoglycan and proteoglycan synthesis
af: Modak, A
Udgivet: (2015)

Characterisation of novel evasins
af: Eaton, J
Udgivet: (2018)

Peptide targeting by spontaneous isopeptide bond formation
af: Zakeri, B, et al.
Udgivet: (2011)

A laboratory manual for general, organic, and biochemistry /
af: 530999 Henrickson, Charles H., et al.
Udgivet: (2011)

General, organic and biological chemistry [electronic resource] /
af: 260120 Arnold, Melvin T.
Udgivet: (2001)

General, organic, and biological chemistry /
af: 388406 Stoker, H. Stephen
Udgivet: (2010)

Fundamentals of organic and biological chemistry /
af: 265039 McMurry, John, et al.
Udgivet: (1994)

Exercises in general, organic, and biological chemistry /
af: 238301 Langsjoen, Arne N.
Udgivet: (1973)

Essentials of general, organic & biological chemistry /
af: 260120 Arnold, Melvin T.
Udgivet: (2001)

General, organic, and biological chemistry /
af: 388406 Stoker, H. Stephen (Howard Stephen), 1939-
Udgivet: (2007)

Towards a small molecule inhibitor of Lactate Dehydrogenase-A
af: Lomas, A
Udgivet: (2011)

Novel protein editing technologies to probe cellular damage
af: Poh, AWJ
Udgivet: (2023)

The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling
af: Emmanuel Laplantine, et al.
Udgivet: (2022-10-01)

Olefin metathesis for site-selective protein modification
af: Lin, YA
Udgivet: (2013)

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.
af: Hay, D
Udgivet: (2014)

Fundamentals of protein structure and function [electronic resource] /
af: 225897 Buxbaum, Engelbert, et al.
Udgivet: (2007)

Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN
af: Saliba, R, et al.
Udgivet: (2014)

Interplay between 2-oxoglutarate oxygenases and cancer: studies on the aspartyl/asparaginyl-beta-hydroxylase
af: Pfeffer, I
Udgivet: (2014)