Entropy-driven genome organization.
DNA and RNA polymerases active on bacterial and human genomes in the crowded environment of a cell are modeled as beads spaced along a string. Aggregation of the large polymerizing complexes increases the entropy of the system through an increase in entropy of the many small crowding molecules; this...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2006
|
| _version_ | 1826290060580880384 |
|---|---|
| author | Marenduzzo, D Micheletti, C Cook, P |
| author_facet | Marenduzzo, D Micheletti, C Cook, P |
| author_sort | Marenduzzo, D |
| collection | OXFORD |
| description | DNA and RNA polymerases active on bacterial and human genomes in the crowded environment of a cell are modeled as beads spaced along a string. Aggregation of the large polymerizing complexes increases the entropy of the system through an increase in entropy of the many small crowding molecules; this occurs despite the entropic costs of looping the intervening DNA. Results of a quantitative cost/benefit analysis are consistent with observations that active polymerases cluster into replication and transcription "factories" in both pro- and eukaryotes. We conclude that the second law of thermodynamics acts through nonspecific entropic forces between engaged polymerases to drive the self-organization of genomes into loops containing several thousands (and sometimes millions) of basepairs. |
| first_indexed | 2024-03-07T02:38:25Z |
| format | Journal article |
| id | oxford-uuid:a997e9a9-0676-484a-873b-2f7fcc6df6d0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:38:25Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:a997e9a9-0676-484a-873b-2f7fcc6df6d02022-03-27T03:09:29ZEntropy-driven genome organization.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a997e9a9-0676-484a-873b-2f7fcc6df6d0EnglishSymplectic Elements at Oxford2006Marenduzzo, DMicheletti, CCook, PDNA and RNA polymerases active on bacterial and human genomes in the crowded environment of a cell are modeled as beads spaced along a string. Aggregation of the large polymerizing complexes increases the entropy of the system through an increase in entropy of the many small crowding molecules; this occurs despite the entropic costs of looping the intervening DNA. Results of a quantitative cost/benefit analysis are consistent with observations that active polymerases cluster into replication and transcription "factories" in both pro- and eukaryotes. We conclude that the second law of thermodynamics acts through nonspecific entropic forces between engaged polymerases to drive the self-organization of genomes into loops containing several thousands (and sometimes millions) of basepairs. |
| spellingShingle | Marenduzzo, D Micheletti, C Cook, P Entropy-driven genome organization. |
| title | Entropy-driven genome organization. |
| title_full | Entropy-driven genome organization. |
| title_fullStr | Entropy-driven genome organization. |
| title_full_unstemmed | Entropy-driven genome organization. |
| title_short | Entropy-driven genome organization. |
| title_sort | entropy driven genome organization |
| work_keys_str_mv | AT marenduzzod entropydrivengenomeorganization AT michelettic entropydrivengenomeorganization AT cookp entropydrivengenomeorganization |