The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.
Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
American Society of Hematology
2007
|
| _version_ | 1826290065344561152 |
|---|---|
| author | Menzel, S Jiang, J Silver, N Gallagher, J Cunningham, J Surdulescu, G Lathrop, M Farrall, M Spector, T Thein, S |
| author_facet | Menzel, S Jiang, J Silver, N Gallagher, J Cunningham, J Surdulescu, G Lathrop, M Farrall, M Spector, T Thein, S |
| author_sort | Menzel, S |
| collection | OXFORD |
| description | Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematologic parameters. Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans. |
| first_indexed | 2024-03-07T02:38:29Z |
| format | Journal article |
| id | oxford-uuid:a99ed1fc-49f9-490c-84f1-b165d8cf1130 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:38:29Z |
| publishDate | 2007 |
| publisher | American Society of Hematology |
| record_format | dspace |
| spelling | oxford-uuid:a99ed1fc-49f9-490c-84f1-b165d8cf11302022-03-27T03:09:39ZThe HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a99ed1fc-49f9-490c-84f1-b165d8cf1130EnglishSymplectic Elements at OxfordAmerican Society of Hematology2007Menzel, SJiang, JSilver, NGallagher, JCunningham, JSurdulescu, GLathrop, MFarrall, MSpector, TThein, SCommon sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematologic parameters. Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans. |
| spellingShingle | Menzel, S Jiang, J Silver, N Gallagher, J Cunningham, J Surdulescu, G Lathrop, M Farrall, M Spector, T Thein, S The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans. |
| title | The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans. |
| title_full | The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans. |
| title_fullStr | The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans. |
| title_full_unstemmed | The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans. |
| title_short | The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans. |
| title_sort | hbs1l myb intergenic region on chromosome 6q23 3 influences erythrocyte platelet and monocyte counts in humans |
| work_keys_str_mv | AT menzels thehbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT jiangj thehbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT silvern thehbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT gallagherj thehbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT cunninghamj thehbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT surdulescug thehbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT lathropm thehbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT farrallm thehbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT spectort thehbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT theins thehbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT menzels hbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT jiangj hbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT silvern hbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT gallagherj hbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT cunninghamj hbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT surdulescug hbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT lathropm hbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT farrallm hbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT spectort hbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans AT theins hbs1lmybintergenicregiononchromosome6q233influenceserythrocyteplateletandmonocytecountsinhumans |