Different mechanisms underlie the long‐term regulation of pyruvate dehydrogenase kinase (PDHK) by tri‐iodothyronine in heart and liver

Different mechanisms underlie the long‐term regulation of pyruvate dehydrogenase kinase (PDHK) by tri‐iodothyronine in heart and liver

Antibodies to purified recombinant PDHKII were used for ELISAs of PDHKII in mitochondrial extracts. In liver, hyperthyroidism elicited a 2.3‐fold increase in PDHK activity (P<0.01) which was accompanied by a significant 1.5‐fold (P<0.001) increase in the amount of mitochondrial immunor...

Descripció completa

Dades bibliogràfiques
Autors principals:	Priestman, D, Donald, E, Holness, M, al., E
Format:	Journal article
Publicat:	Wiley 1997

Ítems similars

Inhibition of pyruvate dehydrogenase kinase by pyruvate in cultured cardiac myocytes
per: Priestman, D, et al.
Publicat: (1997)

Role of protein synthesis and of fatty acid metabolism in the longer-term regulation of pyruvate dehydrogenase kinase
per: Priestman, D, et al.
Publicat: (1994)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
per: Ji Yun Jeong, et al.
Publicat: (2012-10-01)

Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma.
per: Koukourakis, M, et al.
Publicat: (2005)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
per: In-Kyu Lee
Publicat: (2014-06-01)

Pyruvate Dehydrogenase and Pyruvate Dehydrogenase Kinase Expression in Non Small Cell Lung Cancer and Tumor-Associated Stroma
per: Michael I. Koukourakis, et al.
Publicat: (2005-01-01)

Pyruvate Dehydrogenase Kinase as a Novel Therapeutic Target in Oncology
per: Gopinath eSutendra, et al.
Publicat: (2013-03-01)

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
per: Nam Ho Jeoung
Publicat: (2015-06-01)

Pyruvate Dehydrogenase Kinase 4: A Key Mediator for Metabolic Regulation of Liver Regeneration
per: James Burdick, et al.
Publicat: (2020-04-01)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
per: Mariana Galvão Ferrarini, et al.
Publicat: (2021-02-01)

The Tri-iodothyronine (T3) Level Is a Prognostic Factor for Patients With Advanced NSCLC: Receiving Immune Checkpoint Inhibitors and Is Associated With Liver Metastasis
per: Yoonjoo Kim, et al.
Publicat: (2022-12-01)

Low tri-iodothyronine syndrome improves the risk prediction for mortality in patients with acute heart failure: A prospective observational cohort study
per: Shen-Gen Liao, et al.
Publicat: (2021-01-01)

Pyruvate dehydrogenase kinase regulates macrophage polarization in metabolic and inflammatory diseases
per: Chenyu Li, et al.
Publicat: (2023-12-01)

Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
per: Jaechan Leem, et al.
Publicat: (2016-03-01)

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
per: Forteza, MJ, et al.
Publicat: (2023)

Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis
per: Manasa K. Nayak, et al.
Publicat: (2018-08-01)

Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens
per: Kazuhisa Honda, et al.
Publicat: (2017-10-01)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
per: Sungmi Park, et al.
Publicat: (2018-08-01)

Is It T3 Thyrotoxicosis? A Case of Falsely Elevated Tri-Iodothyronine (T3) Levels Leading to a Diagnosis of Multiple Myeloma
per: Nanik Ram, et al.
Publicat: (2019-01-01)

Comparison of serum levels of Tri‐iodothyronine (T3), Thyroxine (T4), and Thyroid‐Stimulating Hormone (TSH) in preeclampsia and normal pregnancy
per: Nayereh Khadem, et al.
Publicat: (2012-01-01)

Iodothyronine deiodinases and reduced sensitivity to thyroid hormones
per: Rosa Maria Paragliola, et al.
Publicat: (2020-01-01)

Inhibition of Pyruvate Dehydrogenase in the Heart as an Initiating Event in the Development of Diabetic Cardiomyopathy
per: Abdallah Elnwasany, et al.
Publicat: (2023-03-01)

Pyruvate dehydrogenase kinase 4 promotes ubiquitin–proteasome system‐dependent muscle atrophy
per: Ibotombi Singh Sinam, et al.
Publicat: (2022-12-01)

Comparison of docking procedures and its efficiency for Betasecretase, Aromatase and Pyruvate dehydrogenase kinase inhibitors
per: Zahra Rezaei, et al.
Publicat: (2017-03-01)

Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes.
per: Rongya Tao, et al.
Publicat: (2013-01-01)

Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype
per: Byong-Keol Min, et al.
Publicat: (2019-05-01)

Novel Dichloroacetophenone-Based PDHK1 Inhibitors as Potent Anticancer Agents
per: Wu P, et al.
Publicat: (2024-10-01)

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation
per: Allison K. Meyers, et al.
Publicat: (2023-01-01)

Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation
per: Abu Jubayer Hossain, et al.
Publicat: (2022-05-01)

Regulation of type 1 iodothyronine deiodinase by LXRα.
per: Yoriko Sakane, et al.
Publicat: (2017-01-01)

Effect of Iodothyronines on Thermogenesis: Focus on Brown Adipose Tissue
per: Federica Cioffi, et al.
Publicat: (2018-05-01)

A Halogen Bonding Perspective on Iodothyronine Deiodinase Activity
per: Eric S. Marsan, et al.
Publicat: (2020-03-01)

The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4
per: Min-Ji Kim, et al.
Publicat: (2023-03-01)

Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal InflammationSummary
per: Hoyul Lee, et al.
Publicat: (2023-01-01)

Pyruvate dehydrogenase kinase 1 promotes neuronal apoptosis upon Japanese encephalitis virus infection
per: Surajit Chakraborty, et al.
Publicat: (2022-12-01)

ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis
per: Chi-Ruei Huang, et al.
Publicat: (2021-01-01)

Hemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity
per: Ling Jin, et al.
Publicat: (2020-12-01)

Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
per: Nilanjana Chatterjee, et al.
Publicat: (2019-08-01)

Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury
per: Alexa Thibodeau, et al.
Publicat: (2016-01-01)

Pyruvate kinase deficiency
per: Alberto Zanella, et al.
Publicat: (2007-06-01)