Different mechanisms underlie the long‐term regulation of pyruvate dehydrogenase kinase (PDHK) by tri‐iodothyronine in heart and liver

Different mechanisms underlie the long‐term regulation of pyruvate dehydrogenase kinase (PDHK) by tri‐iodothyronine in heart and liver

Antibodies to purified recombinant PDHKII were used for ELISAs of PDHKII in mitochondrial extracts. In liver, hyperthyroidism elicited a 2.3‐fold increase in PDHK activity (P<0.01) which was accompanied by a significant 1.5‐fold (P<0.001) increase in the amount of mitochondrial immunor...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Priestman, D, Donald, E, Holness, M, al., E
Μορφή:	Journal article
Έκδοση:	Wiley 1997

Παρόμοια τεκμήρια

Inhibition of pyruvate dehydrogenase kinase by pyruvate in cultured cardiac myocytes
ανά: Priestman, D, κ.ά.
Έκδοση: (1997)

Role of protein synthesis and of fatty acid metabolism in the longer-term regulation of pyruvate dehydrogenase kinase
ανά: Priestman, D, κ.ά.
Έκδοση: (1994)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
ανά: Ji Yun Jeong, κ.ά.
Έκδοση: (2012-10-01)

Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma.
ανά: Koukourakis, M, κ.ά.
Έκδοση: (2005)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
ανά: In-Kyu Lee
Έκδοση: (2014-06-01)

Pyruvate Dehydrogenase and Pyruvate Dehydrogenase Kinase Expression in Non Small Cell Lung Cancer and Tumor-Associated Stroma
ανά: Michael I. Koukourakis, κ.ά.
Έκδοση: (2005-01-01)

Pyruvate Dehydrogenase Kinase as a Novel Therapeutic Target in Oncology
ανά: Gopinath eSutendra, κ.ά.
Έκδοση: (2013-03-01)

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
ανά: Nam Ho Jeoung
Έκδοση: (2015-06-01)

Pyruvate Dehydrogenase Kinase 4: A Key Mediator for Metabolic Regulation of Liver Regeneration
ανά: James Burdick, κ.ά.
Έκδοση: (2020-04-01)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
ανά: Mariana Galvão Ferrarini, κ.ά.
Έκδοση: (2021-02-01)

The Tri-iodothyronine (T3) Level Is a Prognostic Factor for Patients With Advanced NSCLC: Receiving Immune Checkpoint Inhibitors and Is Associated With Liver Metastasis
ανά: Yoonjoo Kim, κ.ά.
Έκδοση: (2022-12-01)

Low tri-iodothyronine syndrome improves the risk prediction for mortality in patients with acute heart failure: A prospective observational cohort study
ανά: Shen-Gen Liao, κ.ά.
Έκδοση: (2021-01-01)

Pyruvate dehydrogenase kinase regulates macrophage polarization in metabolic and inflammatory diseases
ανά: Chenyu Li, κ.ά.
Έκδοση: (2023-12-01)

Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
ανά: Jaechan Leem, κ.ά.
Έκδοση: (2016-03-01)

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
ανά: Forteza, MJ, κ.ά.
Έκδοση: (2023)

Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis
ανά: Manasa K. Nayak, κ.ά.
Έκδοση: (2018-08-01)

Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens
ανά: Kazuhisa Honda, κ.ά.
Έκδοση: (2017-10-01)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
ανά: Sungmi Park, κ.ά.
Έκδοση: (2018-08-01)

Is It T3 Thyrotoxicosis? A Case of Falsely Elevated Tri-Iodothyronine (T3) Levels Leading to a Diagnosis of Multiple Myeloma
ανά: Nanik Ram, κ.ά.
Έκδοση: (2019-01-01)

Comparison of serum levels of Tri‐iodothyronine (T3), Thyroxine (T4), and Thyroid‐Stimulating Hormone (TSH) in preeclampsia and normal pregnancy
ανά: Nayereh Khadem, κ.ά.
Έκδοση: (2012-01-01)

Iodothyronine deiodinases and reduced sensitivity to thyroid hormones
ανά: Rosa Maria Paragliola, κ.ά.
Έκδοση: (2020-01-01)

Inhibition of Pyruvate Dehydrogenase in the Heart as an Initiating Event in the Development of Diabetic Cardiomyopathy
ανά: Abdallah Elnwasany, κ.ά.
Έκδοση: (2023-03-01)

Pyruvate dehydrogenase kinase 4 promotes ubiquitin–proteasome system‐dependent muscle atrophy
ανά: Ibotombi Singh Sinam, κ.ά.
Έκδοση: (2022-12-01)

Comparison of docking procedures and its efficiency for Betasecretase, Aromatase and Pyruvate dehydrogenase kinase inhibitors
ανά: Zahra Rezaei, κ.ά.
Έκδοση: (2017-03-01)

Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes.
ανά: Rongya Tao, κ.ά.
Έκδοση: (2013-01-01)

Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype
ανά: Byong-Keol Min, κ.ά.
Έκδοση: (2019-05-01)

Novel Dichloroacetophenone-Based PDHK1 Inhibitors as Potent Anticancer Agents
ανά: Wu P, κ.ά.
Έκδοση: (2024-10-01)

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation
ανά: Allison K. Meyers, κ.ά.
Έκδοση: (2023-01-01)

Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation
ανά: Abu Jubayer Hossain, κ.ά.
Έκδοση: (2022-05-01)

Regulation of type 1 iodothyronine deiodinase by LXRα.
ανά: Yoriko Sakane, κ.ά.
Έκδοση: (2017-01-01)

Effect of Iodothyronines on Thermogenesis: Focus on Brown Adipose Tissue
ανά: Federica Cioffi, κ.ά.
Έκδοση: (2018-05-01)

A Halogen Bonding Perspective on Iodothyronine Deiodinase Activity
ανά: Eric S. Marsan, κ.ά.
Έκδοση: (2020-03-01)

The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4
ανά: Min-Ji Kim, κ.ά.
Έκδοση: (2023-03-01)

Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal InflammationSummary
ανά: Hoyul Lee, κ.ά.
Έκδοση: (2023-01-01)

Pyruvate dehydrogenase kinase 1 promotes neuronal apoptosis upon Japanese encephalitis virus infection
ανά: Surajit Chakraborty, κ.ά.
Έκδοση: (2022-12-01)

ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis
ανά: Chi-Ruei Huang, κ.ά.
Έκδοση: (2021-01-01)

Hemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity
ανά: Ling Jin, κ.ά.
Έκδοση: (2020-12-01)

Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
ανά: Nilanjana Chatterjee, κ.ά.
Έκδοση: (2019-08-01)

Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury
ανά: Alexa Thibodeau, κ.ά.
Έκδοση: (2016-01-01)

Pyruvate kinase deficiency
ανά: Alberto Zanella, κ.ά.
Έκδοση: (2007-06-01)