SMAD2/3-SMYD2 and developmental transcription factors cooperate with cell cycle inhibitors to guide tissue formation

SMAD2/3-SMYD2 and developmental transcription factors cooperate with cell cycle inhibitors to guide tissue formation

Tissue formation and organ homeostasis are achieved by precise coordination of proliferation and differentiation of stem cells and progenitors. While deregulation of these processes can result in degenerative disease or cancer, their molecular interplays remain unclear. Here we show that the switch...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Militi, S, Nibhani, R, Pook, M, Pauklin, S
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	Oxford University Press 2024

Míreanna comhchosúla

RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling
de réir: Militi, S, et al.
Foilsithe / Cruthaithe: (2023)

RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling
de réir: Stefania Militi, et al.
Foilsithe / Cruthaithe: (2023-09-01)

Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis
de réir: Kwangho Kim, et al.
Foilsithe / Cruthaithe: (2023-05-01)

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma
de réir: Feng, Y, et al.
Foilsithe / Cruthaithe: (2023)

SMYD3 induces sorafenib resistance by activating SMAD2/3-mediated epithelial-mesenchymal transition in hepatocellular carcinoma
de réir: Shanshan Wang, et al.
Foilsithe / Cruthaithe: (2023-07-01)

KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics
de réir: Mouti, MA, et al.
Foilsithe / Cruthaithe: (2023)

Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
de réir: Michael J Thomenius, et al.
Foilsithe / Cruthaithe: (2018-01-01)

Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation
de réir: Madrigal, P, et al.
Foilsithe / Cruthaithe: (2023)

ZNF8 Orchestrates with Smad3 to Promote Lung Metastasis by Recruiting SMYD3 in Breast Cancer
de réir: Wenwen Geng, et al.
Foilsithe / Cruthaithe: (2024-10-01)

Emerging epigenetic therapies: protein arginine methyltransferase inhibitors
de réir: Pook, H, et al.
Foilsithe / Cruthaithe: (2023)

SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells
de réir: Bradley J. Toghill, et al.
Foilsithe / Cruthaithe: (2018-03-01)

KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics
de réir: Mai Abdel Mouti, et al.
Foilsithe / Cruthaithe: (2023-09-01)

Characterizing the Role of SMYD2 in Mammalian Embryogenesis—Future Directions
de réir: Dillon K. Jarrell, et al.
Foilsithe / Cruthaithe: (2020-05-01)

Cardiac deletion of Smyd2 is dispensable for mouse heart development.
de réir: Florian Diehl, et al.
Foilsithe / Cruthaithe: (2010-03-01)

Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation
de réir: Pedro Madrigal, et al.
Foilsithe / Cruthaithe: (2023-01-01)

The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms
de réir: Chang, C-H, et al.
Foilsithe / Cruthaithe: (2024)

TGFB1/INHBA homodimer/nodal-SMAD2/3 signaling network: a pivotal molecular target in PDAC treatment
de réir: Abdel Mouti, M, et al.
Foilsithe / Cruthaithe: (2021)

Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis
de réir: Yi Zeng, et al.
Foilsithe / Cruthaithe: (2019-11-01)

Synergistic anticancer effects of SMYD2 inhibitor BAY-598 and doxorubicin in non-small cell lung cancer
de réir: Jiaqi Meng, et al.
Foilsithe / Cruthaithe: (2024-06-01)

Anticancer Impact of Nitric Oxide (NO) and NO Combination with SMYD-3 Inhibitor on Breast Carcinomas
de réir: Jenna L. Gordon, et al.
Foilsithe / Cruthaithe: (2021-11-01)

Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN
de réir: Makoto Nakakido, et al.
Foilsithe / Cruthaithe: (2015-04-01)

The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11
de réir: Daniela Boehm, et al.
Foilsithe / Cruthaithe: (2023-03-01)

Structural Analysis of SMYD3 Lysine Methyltransferase for the Development of Competitive and Specific Enzyme Inhibitors
de réir: Dillon K. Jarrell, et al.
Foilsithe / Cruthaithe: (2021-12-01)

A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development.
de réir: Elizabeth C Thompson, et al.
Foilsithe / Cruthaithe: (2008-08-01)

Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis
de réir: Alexandre G. Casanova, et al.
Foilsithe / Cruthaithe: (2024-01-01)

Histone methyltransferase Smyd2 contributes to blood‐brain barrier breakdown in stroke
de réir: Jinghuan Wang, et al.
Foilsithe / Cruthaithe: (2022-03-01)

SMYD2 promotes tumorigenesis and metastasis of lung adenocarcinoma through RPS7
de réir: Lei Wu, et al.
Foilsithe / Cruthaithe: (2021-05-01)

SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells
de réir: Yang Yang, et al.
Foilsithe / Cruthaithe: (2022-12-01)

The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms
de réir: Chao-Hui Chang, et al.
Foilsithe / Cruthaithe: (2024-04-01)

Host factor SMYD3 is recruited by Ebola virus nucleoprotein to facilitate viral mRNA transcription
de réir: Jingliang Chen, et al.
Foilsithe / Cruthaithe: (2019-01-01)

Pharmacological inhibition of SMYD2 protects against cisplatin-induced renal fibrosis and inflammation
de réir: Min Chen, et al.
Foilsithe / Cruthaithe: (2023-09-01)

Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation
de réir: Haibi Su, et al.
Foilsithe / Cruthaithe: (2022-10-01)

SMYD2 aggravates gastrointestinal stromal tumor via upregulation of EZH2 and downregulation of TET1
de réir: Yong Ji, et al.
Foilsithe / Cruthaithe: (2022-06-01)

SMYD3 drives cell cycle and epithelial-mesenchymal transition pathways through dual gene transcriptional repression and activation in HPV-negative head and neck cancer
de réir: Madhavi Murali, et al.
Foilsithe / Cruthaithe: (2025-01-01)

Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species.
de réir: Eduardo Calpena, et al.
Foilsithe / Cruthaithe: (2015-01-01)

Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D
de réir: Pauklin, S, et al.
Foilsithe / Cruthaithe: (2016)

SMYD proteins in immunity: dawning of a new era
de réir: Maysaa Doughan, et al.
Foilsithe / Cruthaithe: (2016-10-01)

SMYD1, an SRF-Interacting Partner, Is Involved in Angiogenesis.
de réir: Xiangli Ye, et al.
Foilsithe / Cruthaithe: (2016-01-01)

Author Correction: Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis
de réir: Alexandre G. Casanova, et al.
Foilsithe / Cruthaithe: (2024-03-01)

The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3–SRF axis
de réir: Xiaoxuan Zhong, et al.
Foilsithe / Cruthaithe: (2024-02-01)