IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma

IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma

<p>Treatment with immune checkpoint blockade (ICB) frequently triggers immune-related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving ICB for melanoma, we observed increased severe irAE risk in minor allele carriers of rs16906115, intronic to&nbsp;<em&g...

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Bibliographic Details
Main Authors: Taylor, CA, Watson, RA, Tong, O, Ye, W, Nassiri, I, Gilchrist, JJ, de Los Aires, AV, Sharma, PK, Koturan, S, Cooper, RA, Woodcock, VK, Jungkurth, E, Shine, B, Coupe, N, Payne, MJ, Church, DN, Naranbhai, V, Groha, S, Emery, P, Mankia, K, Freedman, ML, Choueiri, TK, Middleton, MR, Gusev, A, Fairfax, BP
Format: Journal article
Language:English
Published: Springer Nature 2022

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