Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1
Tethered enzymatic reactions are ubiquitous in signalling networks but are poorly understood. Here, a novel mathematical analysis is established for tethered signalling reactions in surface plasmon resonance (SPR). Applying the method to the phosphatase SHP-1 interacting with a phosphorylated tether...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Published: |
American Association for the Advancement of Science: Science Advances
2017
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