Physiologically-regulated low density lipoprotein receptor (LDLR) expression vectors for the treatment of familial hypercholesterolemia

Physiologically-regulated low density lipoprotein receptor (LDLR) expression vectors for the treatment of familial hypercholesterolemia

Bibliographic Details
Main Authors:	Hibbitt, O, Carroll, F, Seymour, L, Channon, K, Wade-Martins, R
Format:	Conference item
Published:	2008

Similar Items

Physiological Regulation and Long Term Expression of the Low Density Lipoprotein Receptor Transgene In Vivo from Genomic DNA Mini-Gene Constructs
by: Hibbitt, O, et al.
Published: (2009)

RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo.
by: Hibbitt, O, et al.
Published: (2012)

RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo
by: Hibbitt, O, et al.
Published: (2012)

Long-term physiologically regulated expression of the low-density lipoprotein receptor in vivo using genomic DNA mini-gene constructs.
by: Hibbitt, O, et al.
Published: (2010)

Analysis of the low density lipoprotein receptor gene (<i>LDLR</i>) mutation spectrum in Russian familial hypercholesterolemia
by: V. B. Vasilyev, et al.
Published: (2022-06-01)

Targeted Gene Knockdown of HMG CoA Reductase Increases Transgene Expression from Genomic DNA LDLR Mini-Gene Vectors In Vitro and In Vivo: Increased Transgene Expression from Genomic LDLR Mini-Gene Vectors In Vitro and In Vivo Following Targeted Knockdown of HMG CoA Reductase
by: Hibbitt, O, et al.
Published: (2010)

LDLR c.415G > A causes familial hypercholesterolemia by weakening LDLR binding to LDL
by: Kaihan Wang, et al.
Published: (2024-03-01)

Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells.
by: Wade-Martins, R, et al.
Published: (2003)

LDLR gene’s promoter region hypermethylation in patients with familial hypercholesterolemia
by: R. A. Zorzo, et al.
Published: (2023-06-01)

Therapeutic targets of hypercholesterolemia: HMGCR and LDLR
by: Ma S, et al.
Published: (2019-08-01)

Novel Tools for Comprehensive Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants
by: Jacek Jasiecki, et al.
Published: (2023-07-01)

Lipoprotein(a) in Familial Hypercholesterolemia
by: Erin O. Jacob, BMSc, et al.
Published: (2024-01-01)

Delivery and long-term expression of a 135 kb LDLR genomic DNA locus in vivo by hydrodynamic tail vein injection.
by: Hibbitt, O, et al.
Published: (2007)

Low-density lipoprotein receptor genotypes modify the sera metabolome of patients with homozygous familial hypercholesterolemia
by: Zhiyong Du, et al.
Published: (2022-11-01)

Screening and verifying the mutations in the LDLR and APOB genes in a Chinese family with familial hypercholesterolemia
by: Xian Lv, et al.
Published: (2023-10-01)

Phenotypical features of heterozygous familial hypercholesterolemia in individuals with LDLR or APOB gene mutations
by: A. N. Meshkov, et al.
Published: (1970-01-01)

A case report of an Egyptian family with familial hypercholesterolemia and an exonic LINE‐1 insertion in LDLR
by: Yongjun Song, et al.
Published: (2024-03-01)

iPSC-Derived Endothelial Cells Reveal LDLR Dysfunction and Dysregulated Gene Expression Profiles in Familial Hypercholesterolemia
by: Irina S. Zakharova, et al.
Published: (2024-01-01)

In vitro assessment of the pathogenicity of the LDLR c.2160delC variant in familial hypercholesterolemia
by: Shaoyi Lin, et al.
Published: (2023-06-01)

Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein Apheresis
by: Akl C. Fahed, et al.
Published: (2012-11-01)

High capacity extrachromosomal gene expression vectors.
by: Hibbitt, O, et al.
Published: (2011)

Familial hypercholesterolemia in St.-Petersburg: the known and novel mutations found in the low density lipoprotein receptor gene in Russia
by: Konstantinov Vladimir O, et al.
Published: (2005-02-01)

Novel LDLR Variant in Familial Hypercholesterolemia: NGS-Based Identification, In Silico Characterization, and Pharmacogenetic Insights
by: Mohammad Athar, et al.
Published: (2023-07-01)

An S/MAR-based infectious episomal genomic DNA expression vector provides long-term regulated functional complementation of LDLR deficiency
by: Lufino, M, et al.
Published: (2007)

An S/MAR-based infectious episomal genomic DNA expression vector provides long-term regulated functional complementation of LDLR deficiency.
by: Lufino, M, et al.
Published: (2007)

Episomal non-viral gene therapy vectors slow progression of atherosclerosis in a model of familial hypercholesterolemia
by: Kerr, A, et al.
Published: (2016)

Hepatic Overexpression of Soluble Urokinase Receptor (uPAR) Suppresses Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR-/-) Mice.
by: Jan Larmann, et al.
Published: (2015-01-01)

Genetic polymorphisms in LDLR, APOB, PCSK9 and other lipid related genes associated with familial hypercholesterolemia in Malaysia.
by: Say-Hean Lye, et al.
Published: (2013-01-01)

Erratum: Decreased serum PON1 arylesterase activity in familial hypercholesterolemia patients with a mutated LDLR gene
Published: (2019-05-01)

Multiple LDLR class A repeats on very‐low‐density lipoprotein receptor promote the cross‐species transmission of Semliki Forest virus
by: Ruolan Hu, et al.
Published: (2023-10-01)

Elevated Lipoprotein(a) Level Influences Familial Hypercholesterolemia Diagnosis
by: Uliana V. Chubykina, et al.
Published: (2022-01-01)

Lipoprotein(a) Genotype Influences the Clinical Diagnosis of Familial Hypercholesterolemia
by: Elena Olmastroni, et al.
Published: (2023-05-01)

Allicin and Capsaicin Ameliorated Hypercholesterolemia by Upregulating LDLR and Downregulating PCSK9 Expression in HepG2 Cells
by: Nantiya Nawaka, et al.
Published: (2022-11-01)

Low-Density Lipoprotein Receptor (LDLR) Is Involved in Internalization of Lentiviral Particles Pseudotyped with SARS-CoV-2 Spike Protein in Ocular Cells
by: Sheetal Uppal, et al.
Published: (2023-07-01)

Low-density lipoprotein cholesterol goal attainment in patients with clinical evidence of familial hypercholesterolemia and elevated Lp(a)
by: Andrea Schwarz, et al.
Published: (2022-11-01)

Decreased Efficiency of Very-Low-Density Lipoprotein Lipolysis Is Linked to Both Hypertriglyceridemia and Hypercholesterolemia, but It Can Be Counteracted by High-Density Lipoprotein
by: Ewa Wieczorek, et al.
Published: (2021-04-01)

Lipoprotein(a) is associated with DNA damage in patients with heterozygous familial hypercholesterolemia
by: Ewelina Woźniak, et al.
Published: (2024-01-01)

Familial Hypercholesterolemia and Lipoprotein(a): A Gordian Knot in Cardiovascular Prevention
by: Amalia Despoina Koutsogianni, et al.
Published: (2022-11-01)

Identification of a novel LDLR p.Glu179Met variant in Thai families with familial hypercholesterolemia and response to treatment with PCSK9 inhibitor
by: Burabha Pussadhamma, et al.
Published: (2024-03-01)

An LDLR missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential of early cardiovascular disease intervention
by: Jørsboe, E, et al.
Published: (2022)