Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol
We report the outcome for children and young people with Down syndrome-associated acute lymphoblastic leukaemia (DS-ALL) treated on a contemporary protocol. Compared with non-DS ALL, patients with DS-ALL had an inferior event-free survival (65·6% vs. 87·7% at 5 years; P < 0·00005) and overall...
| Main Authors: | , , , , , , , |
|---|---|
| פורמט: | Journal article |
| שפה: | English |
| יצא לאור: |
Blackwell Publishing Ltd
2014
|
| _version_ | 1826290135121002496 |
|---|---|
| author | Patrick, K Wade, R Goulden, N Rowntree, C Hough, R Moorman, A Mitchell, C Vora, A |
| author_facet | Patrick, K Wade, R Goulden, N Rowntree, C Hough, R Moorman, A Mitchell, C Vora, A |
| author_sort | Patrick, K |
| collection | OXFORD |
| description | We report the outcome for children and young people with Down syndrome-associated acute lymphoblastic leukaemia (DS-ALL) treated on a contemporary protocol. Compared with non-DS ALL, patients with DS-ALL had an inferior event-free survival (65·6% vs. 87·7% at 5 years; P < 0·00005) and overall survival (70·0% vs. 92·2%; P < 0·00005). Excess treatment-related mortality - was primarily responsible for the worse outcomes for DS-ALL (21·6% at 5 years, vs. 3·3%, P < 0·00005). Minimal residual disease (MRD) risk status was highly discriminant for relapse in DS patients with 0/28 relapses in the MRD low risk group. © 2014 John Wiley and Sons Ltd. |
| first_indexed | 2024-03-07T02:39:33Z |
| format | Journal article |
| id | oxford-uuid:a9f75ac7-ee76-4ef7-91e2-df0ba8e9af57 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:39:33Z |
| publishDate | 2014 |
| publisher | Blackwell Publishing Ltd |
| record_format | dspace |
| spelling | oxford-uuid:a9f75ac7-ee76-4ef7-91e2-df0ba8e9af572022-03-27T03:11:58ZOutcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocolJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a9f75ac7-ee76-4ef7-91e2-df0ba8e9af57EnglishSymplectic Elements at OxfordBlackwell Publishing Ltd2014Patrick, KWade, RGoulden, NRowntree, CHough, RMoorman, AMitchell, CVora, AWe report the outcome for children and young people with Down syndrome-associated acute lymphoblastic leukaemia (DS-ALL) treated on a contemporary protocol. Compared with non-DS ALL, patients with DS-ALL had an inferior event-free survival (65·6% vs. 87·7% at 5 years; P < 0·00005) and overall survival (70·0% vs. 92·2%; P < 0·00005). Excess treatment-related mortality - was primarily responsible for the worse outcomes for DS-ALL (21·6% at 5 years, vs. 3·3%, P < 0·00005). Minimal residual disease (MRD) risk status was highly discriminant for relapse in DS patients with 0/28 relapses in the MRD low risk group. © 2014 John Wiley and Sons Ltd. |
| spellingShingle | Patrick, K Wade, R Goulden, N Rowntree, C Hough, R Moorman, A Mitchell, C Vora, A Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol |
| title | Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol |
| title_full | Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol |
| title_fullStr | Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol |
| title_full_unstemmed | Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol |
| title_short | Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol |
| title_sort | outcome of down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol |
| work_keys_str_mv | AT patrickk outcomeofdownsyndromeassociatedacutelymphoblasticleukaemiatreatedonacontemporaryprotocol AT wader outcomeofdownsyndromeassociatedacutelymphoblasticleukaemiatreatedonacontemporaryprotocol AT gouldenn outcomeofdownsyndromeassociatedacutelymphoblasticleukaemiatreatedonacontemporaryprotocol AT rowntreec outcomeofdownsyndromeassociatedacutelymphoblasticleukaemiatreatedonacontemporaryprotocol AT houghr outcomeofdownsyndromeassociatedacutelymphoblasticleukaemiatreatedonacontemporaryprotocol AT moormana outcomeofdownsyndromeassociatedacutelymphoblasticleukaemiatreatedonacontemporaryprotocol AT mitchellc outcomeofdownsyndromeassociatedacutelymphoblasticleukaemiatreatedonacontemporaryprotocol AT voraa outcomeofdownsyndromeassociatedacutelymphoblasticleukaemiatreatedonacontemporaryprotocol |