The association between conception history and subsequent postpartum depression and/or anxiety: Evidence from the Clinical Practice Research Datalink 1991-2013
Background Infertility, and fertility treatment, are associated with psychological distress that may influence subsequent mental health including postpartum depression and anxiety. Methods Data for women who had a livebirth between 1991 and 2013 were drawn from the Clinical Practice Research Datali...
| Päätekijät: | , , , , , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
Elsevier
2022
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| _version_ | 1826307773649911808 |
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| author | Tianyi, FT Li, Y Alderdice, F Quigley, MA Kurinczuk, JJ Bankhead, C Carson, C |
| author_facet | Tianyi, FT Li, Y Alderdice, F Quigley, MA Kurinczuk, JJ Bankhead, C Carson, C |
| author_sort | Tianyi, FT |
| collection | OXFORD |
| description | Background
Infertility, and fertility treatment, are associated with psychological distress that may influence subsequent mental health including postpartum depression and anxiety.
Methods
Data for women who had a livebirth between 1991 and 2013 were drawn from the Clinical Practice Research Datalink. Conception history prior to their first recorded birth was categorised as ‘no fertility problems’, ‘untreated subfertility’, ovulation induction (OI), and assisted reproductive technologies (ART). Depression and/or anxiety in the 12 months postpartum were identified using records of diagnoses, symptoms, and prescriptions. Prevalence was compared, and odds ratios estimated using multivariable logistic regression.
Results
Of 235,127 mothers, 31,947 (13.6%) had evidence of postpartum depression and/or anxiety. Mothers in the ART group had 22% lower odds of postnatal depression and/or anxiety compared to mothers in the fertile group (OR 0.78; 95% CI [0.70–0.86]; p < 0.0001). Accounting for prior mental health, lifestyle, sociodemographic and pregnancy-related factors reduced the strength of the association (aOR 0.87; 95% CI [0.78–0.97]; p = 0.01). There were no significant associations observed in the untreated subfertility or OI groups.
Limitations
As in any analysis of routine data, the quality of recording is important and some information was unavailable (e.g. education, social support).
Conclusions
Women with a history of subfertility, OI or ART treatment were not at increased risk of postpartum depression and/or anxiety compared to those with no fertility problems. It is important to explore whether women who underwent ART are less likely to experience depression/anxiety or do not seek help when needed, with implications for their health and care.
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| first_indexed | 2024-03-07T07:09:33Z |
| format | Journal article |
| id | oxford-uuid:aa133802-b365-4a3a-96e7-a109a269c3a1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:09:33Z |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:aa133802-b365-4a3a-96e7-a109a269c3a12022-06-01T08:01:27ZThe association between conception history and subsequent postpartum depression and/or anxiety: Evidence from the Clinical Practice Research Datalink 1991-2013Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:aa133802-b365-4a3a-96e7-a109a269c3a1EnglishSymplectic ElementsElsevier2022Tianyi, FTLi, YAlderdice, FQuigley, MAKurinczuk, JJBankhead, CCarson, CBackground Infertility, and fertility treatment, are associated with psychological distress that may influence subsequent mental health including postpartum depression and anxiety. Methods Data for women who had a livebirth between 1991 and 2013 were drawn from the Clinical Practice Research Datalink. Conception history prior to their first recorded birth was categorised as ‘no fertility problems’, ‘untreated subfertility’, ovulation induction (OI), and assisted reproductive technologies (ART). Depression and/or anxiety in the 12 months postpartum were identified using records of diagnoses, symptoms, and prescriptions. Prevalence was compared, and odds ratios estimated using multivariable logistic regression. Results Of 235,127 mothers, 31,947 (13.6%) had evidence of postpartum depression and/or anxiety. Mothers in the ART group had 22% lower odds of postnatal depression and/or anxiety compared to mothers in the fertile group (OR 0.78; 95% CI [0.70–0.86]; p < 0.0001). Accounting for prior mental health, lifestyle, sociodemographic and pregnancy-related factors reduced the strength of the association (aOR 0.87; 95% CI [0.78–0.97]; p = 0.01). There were no significant associations observed in the untreated subfertility or OI groups. Limitations As in any analysis of routine data, the quality of recording is important and some information was unavailable (e.g. education, social support). Conclusions Women with a history of subfertility, OI or ART treatment were not at increased risk of postpartum depression and/or anxiety compared to those with no fertility problems. It is important to explore whether women who underwent ART are less likely to experience depression/anxiety or do not seek help when needed, with implications for their health and care. |
| spellingShingle | Tianyi, FT Li, Y Alderdice, F Quigley, MA Kurinczuk, JJ Bankhead, C Carson, C The association between conception history and subsequent postpartum depression and/or anxiety: Evidence from the Clinical Practice Research Datalink 1991-2013 |
| title | The association between conception history and subsequent postpartum depression and/or anxiety: Evidence from the Clinical Practice Research Datalink 1991-2013 |
| title_full | The association between conception history and subsequent postpartum depression and/or anxiety: Evidence from the Clinical Practice Research Datalink 1991-2013 |
| title_fullStr | The association between conception history and subsequent postpartum depression and/or anxiety: Evidence from the Clinical Practice Research Datalink 1991-2013 |
| title_full_unstemmed | The association between conception history and subsequent postpartum depression and/or anxiety: Evidence from the Clinical Practice Research Datalink 1991-2013 |
| title_short | The association between conception history and subsequent postpartum depression and/or anxiety: Evidence from the Clinical Practice Research Datalink 1991-2013 |
| title_sort | association between conception history and subsequent postpartum depression and or anxiety evidence from the clinical practice research datalink 1991 2013 |
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