Use of megavoltage cine-images for studying intra-thoracic motion during radiotherapy for locally advanced lung cancer.
BACKGROUND AND PURPOSE: Use of planning 4-dimensional CT (4DCT) scans often permits use of smaller target volumes for thoracic tumors but this assumes a reproducible pattern of motion during radiotherapy. We compared cranio-caudal (CC) motion on MV cine-images acquired during treatment with that se...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797087782657589248 |
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| author | Muirhead, R van der Weide, L de Koste, v Cover, K Senan, S |
| author_facet | Muirhead, R van der Weide, L de Koste, v Cover, K Senan, S |
| author_sort | Muirhead, R |
| collection | OXFORD |
| description | BACKGROUND AND PURPOSE: Use of planning 4-dimensional CT (4DCT) scans often permits use of smaller target volumes for thoracic tumors but this assumes a reproducible pattern of motion during radiotherapy. We compared cranio-caudal (CC) motion on MV cine-images acquired during treatment with that seen on planning 4DCT. METHODS AND MATERIALS: A pre-programmable respiratory motion phantom and a software tool for motion assessment were used to validate the use of MV cine-images for motion detection. MV cine-images acquired in 20 patients with node-positive lung cancer were analyzed using the same software. Intra-fraction CC motion on 6 MV cine-images from each patient was compared with CC motion on their planning 4DCT. RESULTS: Software-based motion measurement on MV cine-images from the phantom corresponded to actual motion. Mean CC motion of primary tumor, carina and hilus on 4DCT was 7.3mm (range 2-13.8mm), 6.8mm (1.8-21.2) and 11.0mm (4.2-15.1), respectively. Corresponding intra-fraction motion on MV cine was 4.1mm (0.6-13.6mm); 2.7mm (0-10mm) and 6.0mm (1.8-14.4mm), respectively. The tumor, hilus and carina could be tracked in 95%, 88% and 38% of the MV cine-images, respectively. CONCLUSIONS: Intra-fraction motion can be reliably measured using MV-cine images from a phantom. Motion discrepancies identified on MV cine-images can identify patients in whom planning 4DCT scans are not representative. |
| first_indexed | 2024-03-07T02:40:34Z |
| format | Journal article |
| id | oxford-uuid:aa4d3e66-65d3-407c-9d9d-3497a9e6175a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:40:34Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:aa4d3e66-65d3-407c-9d9d-3497a9e6175a2022-03-27T03:14:14ZUse of megavoltage cine-images for studying intra-thoracic motion during radiotherapy for locally advanced lung cancer.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:aa4d3e66-65d3-407c-9d9d-3497a9e6175aEnglishSymplectic Elements at Oxford2011Muirhead, Rvan der Weide, Lde Koste, vCover, KSenan, S BACKGROUND AND PURPOSE: Use of planning 4-dimensional CT (4DCT) scans often permits use of smaller target volumes for thoracic tumors but this assumes a reproducible pattern of motion during radiotherapy. We compared cranio-caudal (CC) motion on MV cine-images acquired during treatment with that seen on planning 4DCT. METHODS AND MATERIALS: A pre-programmable respiratory motion phantom and a software tool for motion assessment were used to validate the use of MV cine-images for motion detection. MV cine-images acquired in 20 patients with node-positive lung cancer were analyzed using the same software. Intra-fraction CC motion on 6 MV cine-images from each patient was compared with CC motion on their planning 4DCT. RESULTS: Software-based motion measurement on MV cine-images from the phantom corresponded to actual motion. Mean CC motion of primary tumor, carina and hilus on 4DCT was 7.3mm (range 2-13.8mm), 6.8mm (1.8-21.2) and 11.0mm (4.2-15.1), respectively. Corresponding intra-fraction motion on MV cine was 4.1mm (0.6-13.6mm); 2.7mm (0-10mm) and 6.0mm (1.8-14.4mm), respectively. The tumor, hilus and carina could be tracked in 95%, 88% and 38% of the MV cine-images, respectively. CONCLUSIONS: Intra-fraction motion can be reliably measured using MV-cine images from a phantom. Motion discrepancies identified on MV cine-images can identify patients in whom planning 4DCT scans are not representative. |
| spellingShingle | Muirhead, R van der Weide, L de Koste, v Cover, K Senan, S Use of megavoltage cine-images for studying intra-thoracic motion during radiotherapy for locally advanced lung cancer. |
| title | Use of megavoltage cine-images for studying intra-thoracic motion during radiotherapy for locally advanced lung cancer. |
| title_full | Use of megavoltage cine-images for studying intra-thoracic motion during radiotherapy for locally advanced lung cancer. |
| title_fullStr | Use of megavoltage cine-images for studying intra-thoracic motion during radiotherapy for locally advanced lung cancer. |
| title_full_unstemmed | Use of megavoltage cine-images for studying intra-thoracic motion during radiotherapy for locally advanced lung cancer. |
| title_short | Use of megavoltage cine-images for studying intra-thoracic motion during radiotherapy for locally advanced lung cancer. |
| title_sort | use of megavoltage cine images for studying intra thoracic motion during radiotherapy for locally advanced lung cancer |
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