Responses of prolactin and growth hormone to L-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics.
Intravenous infusion of L-tryptophan (LTP) in 18 normal subjects produced a significant increase in plasma prolactin (PRL), growth hormone (GH), and self-ratings of drowsiness. There was no correlation between the PRL and GH responses, or between the hormonal responses and drowsiness. Saline infusio...
| मुख्य लेखकों: | , , , |
|---|---|
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
Springer-Verlag
1985
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| _version_ | 1826290244808343552 |
|---|---|
| author | Cowen, P Gadhvi, H Gosden, B Kolakowska, T |
| author_facet | Cowen, P Gadhvi, H Gosden, B Kolakowska, T |
| author_sort | Cowen, P |
| collection | OXFORD |
| description | Intravenous infusion of L-tryptophan (LTP) in 18 normal subjects produced a significant increase in plasma prolactin (PRL), growth hormone (GH), and self-ratings of drowsiness. There was no correlation between the PRL and GH responses, or between the hormonal responses and drowsiness. Saline infusion did not result in endocrine or psychological changes. The effect of LTP on both PRL and GH was dose-related in that LTP 7.5 g produced greater endocrine responses than 5.0 g. It was not significantly decreased by cyproheptadine, a 5-HT receptor antagonist. Schizophrenic patients receiving neuroleptics had increased PRL response to LTP, possibly because of the drug-induced disinhibition of PRL release. Their GH response to LTP was markedly decreased. The mechanism of this effect requires further investigation. |
| first_indexed | 2024-03-07T02:41:13Z |
| format | Journal article |
| id | oxford-uuid:aa832727-0cd6-48d3-845e-fda92b0ae5c5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:41:13Z |
| publishDate | 1985 |
| publisher | Springer-Verlag |
| record_format | dspace |
| spelling | oxford-uuid:aa832727-0cd6-48d3-845e-fda92b0ae5c52022-03-27T03:15:40ZResponses of prolactin and growth hormone to L-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:aa832727-0cd6-48d3-845e-fda92b0ae5c5EnglishSymplectic Elements at OxfordSpringer-Verlag1985Cowen, PGadhvi, HGosden, BKolakowska, TIntravenous infusion of L-tryptophan (LTP) in 18 normal subjects produced a significant increase in plasma prolactin (PRL), growth hormone (GH), and self-ratings of drowsiness. There was no correlation between the PRL and GH responses, or between the hormonal responses and drowsiness. Saline infusion did not result in endocrine or psychological changes. The effect of LTP on both PRL and GH was dose-related in that LTP 7.5 g produced greater endocrine responses than 5.0 g. It was not significantly decreased by cyproheptadine, a 5-HT receptor antagonist. Schizophrenic patients receiving neuroleptics had increased PRL response to LTP, possibly because of the drug-induced disinhibition of PRL release. Their GH response to LTP was markedly decreased. The mechanism of this effect requires further investigation. |
| spellingShingle | Cowen, P Gadhvi, H Gosden, B Kolakowska, T Responses of prolactin and growth hormone to L-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics. |
| title | Responses of prolactin and growth hormone to L-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics. |
| title_full | Responses of prolactin and growth hormone to L-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics. |
| title_fullStr | Responses of prolactin and growth hormone to L-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics. |
| title_full_unstemmed | Responses of prolactin and growth hormone to L-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics. |
| title_short | Responses of prolactin and growth hormone to L-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics. |
| title_sort | responses of prolactin and growth hormone to l tryptophan infusion effects in normal subjects and schizophrenic patients receiving neuroleptics |
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