Endpoints for clinical trials evaluating disease modification and structural damage in adults with Crohn's disease.

Endpoints for clinical trials evaluating disease modification and structural damage in adults with Crohn's disease.

The management of Crohn's disease is rapidly changing. The advent of potent immunomodulatory and biologic therapies has led to more demanding endpoints for clinical trials than only clinical response and remission. Complete withdrawal of corticosteroids, healing of endoscopically visible lesion...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	D'Haens, G, Fedorak, R, Lémann, M, Feagan, BG, Kamm, M, Cosnes, J, Rutgeerts, P, Marteau, P, Travis, S, Schölmerich, J, Hanauer, S, Sandborn, W
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2009

Παρόμοια τεκμήρια

Central Reading of Endoscopy Endpoints in Inflammatory Bowel Disease Trials.
ανά: Gottlieb, K, κ.ά.
Έκδοση: (2015)

Evolving concepts in phases I and II drug development for Crohn's Disease
ανά: Jairath, V, κ.ά.
Έκδοση: (2016)

Development of the Paris definition of early Crohn's disease for disease-modification trials: results of an international expert opinion process.
ανά: Peyrin-Biroulet, L, κ.ά.
Έκδοση: (2012)

Development of the Crohn's disease digestive damage score, the Lemann score.
ανά: Pariente, B, κ.ά.
Έκδοση: (2011)

A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998.
ανά: Gasche, C, κ.ά.
Έκδοση: (2000)

Evolving concepts in Phase I and II Drug Development for Crohn's Disease.
ανά: Jairath, V, κ.ά.
Έκδοση: (2016)

American gastroenterological association consensus development conference on the use of biologics in the treatment of inflammatory bowel disease, June 21-23, 2006.
ανά: Clark, M, κ.ά.
Έκδοση: (2007)

The Crohn's disease–ulcerative colitis clinical appraisal update: emerging trends in clinical practice
ανά: Sandborn, W, κ.ά.
Έκδοση: (2016)

The future of inflammatory bowel disease management: combining progress in trial design with advances in targeted therapy.
ανά: Travis, S, κ.ά.
Έκδοση: (2012)

European evidence based consensus on the diagnosis and management of Crohn's disease: current management.
ανά: Travis, S, κ.ά.
Έκδοση: (2006)

Biomarker correlation with endoscopic outcomes in patients with Crohn's disease: data from CALM
ανά: Reinisch, W, κ.ά.
Έκδοση: (2018)

Management of Perianal Crohn's Disease
ανά: Paul Rutgeerts
Έκδοση: (2000-01-01)

Development of red flags index for early referral of adults with symptoms and signs suggestive of Crohn’s disease: an IOIBD initiative
ανά: Danese, S, κ.ά.
Έκδοση: (2015)

Steroid-Dependent Crohn’s Disease
ανά: William J Sandborn
Έκδοση: (2000-01-01)

Infliximab in the Treatment of Crohn’s Disease
ανά: Brian Feagan
Έκδοση: (2000-01-01)

Characterization of Mucosal Lesions in Crohn's Disease Scored With Capsule Endoscopy: A Systematic Review
ανά: Miquel Marquès Camí, κ.ά.
Έκδοση: (2021-01-01)

Standardizing scoring conventions for Crohn’s disease endoscopy: An international RAND/UCLA appropriateness study
ανά: Khanna, R, κ.ά.
Έκδοση: (2023)

Effect of tight control management on Crohn's disease (CALM): a multicentre, randomised, controlled phase 3 trial.
ανά: Colombel, J, κ.ά.
Έκδοση: (2017)

Placebo response and remission rates in randomised trials of induction and maintenance therapy for Crohn's disease
ανά: Jairath, V, κ.ά.
Έκδοση: (2016)

Developing an instrument to assess the endoscopic severity of ulcerative colitis: the Ulcerative Colitis Endoscopic Index of Severity (UCEIS).
ανά: Travis, S, κ.ά.
Έκδοση: (2012)

Biosimilars in IBD: hope or expectation?
ανά: Gecse, K, κ.ά.
Έκδοση: (2013)

Risk Factors for Relapse and Recurrence of Ulcerative Colitis and Crohn’s Disease
ανά: Paul Rutgeerts
Έκδοση: (1993-01-01)

Reliability among central readers in the evaluation of endoscopic disease activity in pouchitis
ανά: Samaan, MA, κ.ά.
Έκδοση: (2018)

Biologic Therapies: From Complexity to Clinical Practice in a Changing Environment
ανά: Remo Panaccione, κ.ά.
Έκδοση: (2015-12-01)

The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response?
ανά: D'Haens, G, κ.ά.
Έκδοση: (2011)

Osteoporosis of Crohn’s Disease: A Critical Review
ανά: Neena S Abraham, κ.ά.
Έκδοση: (1996-01-01)

Oropharyngeal Crohn&rsquo;s disease
ανά: Rachid Mohamed, κ.ά.
Έκδοση: (2008-12-01)

Tight control for Crohn's disease with adalimumab-based treatment is cost-effective: an economic assessment of the CALM trial
ανά: Panaccione, R, κ.ά.
Έκδοση: (2019)

Central Endoscopy Reading in Inflammatory Bowel Diseases
ανά: Panés, J, κ.ά.
Έκδοση: (2016)

Misleading pustular plaques of the lower limbs during Crohn's disease: two case reports
ανά: Farhi David, κ.ά.
Έκδοση: (2007-10-01)

Does Smoking Reduce Infliximab’s Effectiveness against Crohn’s Disease?
ανά: Neeraj Narula, κ.ά.
Έκδοση: (2009-01-01)

European evidence-based Consensus on the management of ulcerative colitis: Current management.
ανά: Travis, S, κ.ά.
Έκδοση: (2008)

Reliability and initial validation of the ulcerative colitis endoscopic index of severity.
ανά: Travis, S, κ.ά.
Έκδοση: (2013)

The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].
ανά: Travis, S, κ.ά.
Έκδοση: (2015)

The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations.
ανά: Van Assche, G, κ.ά.
Έκδοση: (2010)

Genotype/phenotype analyses for 53 Crohn's disease associated genetic polymorphisms.
ανά: Camille Jung, κ.ά.
Έκδοση: (2012-01-01)

Predicting, Treating and Preventing Postoperative Recurrence of Crohn’s Disease: The State of the Field
ανά: Anna M Borowiec, κ.ά.
Έκδοση: (2011-01-01)

Crohn’s disease or Crohn’s diseases?
ανά: Arnott, IDR, κ.ά.
Έκδοση: (2003)

The genetic prediction of the clinical response to infliximab in Crohn's disease (CD): A role for polymorphisms in the TNFa and LTA genes?
ανά: De Silva, A, κ.ά.
Έκδοση: (2002)

Intestinal fibrosis is associated with lack of response to Infliximab therapy in Crohn's disease.
ανά: Jessica R de Bruyn, κ.ά.
Έκδοση: (2018-01-01)