Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.
ATP-sensitive potassium (KATP) channels couple cell metabolism to electrical activity by regulating K+ flux across the plasma membrane. Channel closure is mediated by ATP, which binds to the pore-forming subunit (Kir6.2). Here we use homology modelling and ligand docking to construct a model of the...
Үндсэн зохиолчид: | , , , , |
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Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
2005
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