Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.

Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.

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ATP-sensitive potassium channels (K(ATP)) are formed from four pore-forming Kir6.2 subunits complexed with four regulatory sulfonylurea receptor subunits (SUR1 in pancreatic beta-cells, SUR2A in heart). The sensitivity of the channel to different sulfonylureas depends on the SUR isoform. In particul...

書誌詳細
主要な著者:	Ashfield, R, Gribble, F, Ashcroft, S, Ashcroft, F
フォーマット:	Journal article
言語:	English
出版事項:	1999

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