Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.

ATP-sensitive potassium channels (K(ATP)) are formed from four pore-forming Kir6.2 subunits complexed with four regulatory sulfonylurea receptor subunits (SUR1 in pancreatic beta-cells, SUR2A in heart). The sensitivity of the channel to different sulfonylureas depends on the SUR isoform. In particul...

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Príomhchruthaitheoirí: Ashfield, R, Gribble, F, Ashcroft, S, Ashcroft, F
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 1999