Genetics of infectious disease resistance.
The identification of large numbers of candidates genes and the introduction of methodologies for whole-genome screening have provided new opportunities for elucidating the molecular basis of variable susceptibility to major infectious diseases. 12 genes have been implicated in variable susceptibili...
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| Format: | Journal article |
| Language: | English |
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1996
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| _version_ | 1797087914663870464 |
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| author | Hill, A |
| author_facet | Hill, A |
| author_sort | Hill, A |
| collection | OXFORD |
| description | The identification of large numbers of candidates genes and the introduction of methodologies for whole-genome screening have provided new opportunities for elucidating the molecular basis of variable susceptibility to major infectious diseases. 12 genes have been implicated in variable susceptibility to malaria and susceptibility/resistance genes for several other infectious diseases are beginning to be identified. Recent work suggests that large-scale family linkage and population association studies will be a more successful route to human disease genes than extrapolation from mouse models of infection. |
| first_indexed | 2024-03-07T02:42:21Z |
| format | Journal article |
| id | oxford-uuid:aae1f8c0-9590-4a1a-b847-7af0576623a2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:42:21Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:aae1f8c0-9590-4a1a-b847-7af0576623a22022-03-27T03:18:06ZGenetics of infectious disease resistance.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:aae1f8c0-9590-4a1a-b847-7af0576623a2EnglishSymplectic Elements at Oxford1996Hill, AThe identification of large numbers of candidates genes and the introduction of methodologies for whole-genome screening have provided new opportunities for elucidating the molecular basis of variable susceptibility to major infectious diseases. 12 genes have been implicated in variable susceptibility to malaria and susceptibility/resistance genes for several other infectious diseases are beginning to be identified. Recent work suggests that large-scale family linkage and population association studies will be a more successful route to human disease genes than extrapolation from mouse models of infection. |
| spellingShingle | Hill, A Genetics of infectious disease resistance. |
| title | Genetics of infectious disease resistance. |
| title_full | Genetics of infectious disease resistance. |
| title_fullStr | Genetics of infectious disease resistance. |
| title_full_unstemmed | Genetics of infectious disease resistance. |
| title_short | Genetics of infectious disease resistance. |
| title_sort | genetics of infectious disease resistance |
| work_keys_str_mv | AT hilla geneticsofinfectiousdiseaseresistance |