Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13.
The morphogenesis of poxviruses such as vaccinia virus (VACV) sees the virion shape mature from spherical to brick-shaped. Trimeric capsomers of the VACV D13 protein form a transitory, stabilizing lattice on the surface of the initial spherical immature virus particle. The crystal structure of D13 r...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797087922583764992 |
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| author | Bahar, M Graham, S Stuart, D Grimes, J |
| author_facet | Bahar, M Graham, S Stuart, D Grimes, J |
| author_sort | Bahar, M |
| collection | OXFORD |
| description | The morphogenesis of poxviruses such as vaccinia virus (VACV) sees the virion shape mature from spherical to brick-shaped. Trimeric capsomers of the VACV D13 protein form a transitory, stabilizing lattice on the surface of the initial spherical immature virus particle. The crystal structure of D13 reveals that this major scaffolding protein comprises a double β barrel "jelly-roll" subunit arranged as pseudo-hexagonal trimers. These structural features are characteristic of the major capsid proteins of a lineage of large icosahedral double-stranded DNA viruses including human adenovirus and the bacteriophages PRD1 and PM2. Structure-based phylogenetic analysis confirms that VACV belongs to this lineage, suggesting that (analogously to higher organism embryogenesis) early poxvirus morphogenesis reflects their evolution from a lineage of viruses sharing a common icosahedral ancestor. |
| first_indexed | 2024-03-07T02:42:28Z |
| format | Journal article |
| id | oxford-uuid:aaece297-bfaa-4086-a052-b30944b88ecb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:42:28Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:aaece297-bfaa-4086-a052-b30944b88ecb2022-03-27T03:18:25ZInsights into the evolution of a complex virus from the crystal structure of vaccinia virus D13.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:aaece297-bfaa-4086-a052-b30944b88ecbEnglishSymplectic Elements at Oxford2011Bahar, MGraham, SStuart, DGrimes, JThe morphogenesis of poxviruses such as vaccinia virus (VACV) sees the virion shape mature from spherical to brick-shaped. Trimeric capsomers of the VACV D13 protein form a transitory, stabilizing lattice on the surface of the initial spherical immature virus particle. The crystal structure of D13 reveals that this major scaffolding protein comprises a double β barrel "jelly-roll" subunit arranged as pseudo-hexagonal trimers. These structural features are characteristic of the major capsid proteins of a lineage of large icosahedral double-stranded DNA viruses including human adenovirus and the bacteriophages PRD1 and PM2. Structure-based phylogenetic analysis confirms that VACV belongs to this lineage, suggesting that (analogously to higher organism embryogenesis) early poxvirus morphogenesis reflects their evolution from a lineage of viruses sharing a common icosahedral ancestor. |
| spellingShingle | Bahar, M Graham, S Stuart, D Grimes, J Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13. |
| title | Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13. |
| title_full | Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13. |
| title_fullStr | Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13. |
| title_full_unstemmed | Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13. |
| title_short | Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13. |
| title_sort | insights into the evolution of a complex virus from the crystal structure of vaccinia virus d13 |
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