DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes.

DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes.

Quick and clean: A method for Pd-catalyzed Suzuki-Miyaura cross-coupling to iododeoxyuridine (IdU) in DNA is described. Key to the reactivity is the choice of the ligand and the buffer. A covalent [Pd]-DNA intermediate was isolated and characterized. Photocrosslinking probes were generated to trap p...

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Detalhes bibliográficos
Principais autores:	Lercher, L, McGouran, J, Kessler, B, Schofield, C, Davis, B
Formato:	Journal article
Idioma:	English
Publicado em:	2013

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