DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes.

DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes.

Quick and clean: A method for Pd-catalyzed Suzuki-Miyaura cross-coupling to iododeoxyuridine (IdU) in DNA is described. Key to the reactivity is the choice of the ligand and the buffer. A covalent [Pd]-DNA intermediate was isolated and characterized. Photocrosslinking probes were generated to trap p...

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Bibliografiske detaljer
Main Authors:	Lercher, L, McGouran, J, Kessler, B, Schofield, C, Davis, B
Format:	Journal article
Sprog:	English
Udgivet:	2013

Lignende værker

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Phosphine-free Suzuki-Miyaura cross-coupling in aqueous media enables access to 2-C-aryl-glycosides.
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Udgivet: (2012)

Suzuki-Miyaura coupling under microwave enhanced conditions: synthesis of 2-(hetero)aryl benzimidazoles
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An asymmetric Suzuki-Miyaura approach to prostaglandins: Synthesis of Tafluprost
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Recent Developments in the Suzuki-Miyaura Reaction: 2010–2014
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Udgivet: (2015-04-01)

DNA-Compatible Suzuki-Miyaura Cross-Coupling Reaction of Aryl Iodides With (Hetero)Aryl Boronic Acids for DNA-Encoded Libraries
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