Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis.
Valienol-derived allylic C-1 bromides have been used as carbaglycosyl donors for α-xylo configured valienamine pseudodisaccharide synthesis. We synthesised valienamine analogues of the Glc(α1→3)Glc and Glc(α1→3)Man disaccharides representing the linkages cleaved by α-Glucosidase II in N-glycan biosy...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1826290382415069184 |
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| author | Cumpstey, I Ramstadius, C Eszter Borbas, K Alonzi, D Butters, T |
| author_facet | Cumpstey, I Ramstadius, C Eszter Borbas, K Alonzi, D Butters, T |
| author_sort | Cumpstey, I |
| collection | OXFORD |
| description | Valienol-derived allylic C-1 bromides have been used as carbaglycosyl donors for α-xylo configured valienamine pseudodisaccharide synthesis. We synthesised valienamine analogues of the Glc(α1→3)Glc and Glc(α1→3)Man disaccharides representing the linkages cleaved by α-Glucosidase II in N-glycan biosynthesis. These (N1→3)-linked pseudodisaccharides were found to have some α-Glucosidase II inhibitory activity, while two other (N1→6)-linked valienamine pseudodisaccharides failed to inhibit the enzyme. |
| first_indexed | 2024-03-07T02:43:20Z |
| format | Journal article |
| id | oxford-uuid:ab33b7de-c291-4028-9fd1-819f5ef348ef |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:43:20Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:ab33b7de-c291-4028-9fd1-819f5ef348ef2022-03-27T03:20:22ZSynthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ab33b7de-c291-4028-9fd1-819f5ef348efEnglishSymplectic Elements at Oxford2011Cumpstey, IRamstadius, CEszter Borbas, KAlonzi, DButters, TValienol-derived allylic C-1 bromides have been used as carbaglycosyl donors for α-xylo configured valienamine pseudodisaccharide synthesis. We synthesised valienamine analogues of the Glc(α1→3)Glc and Glc(α1→3)Man disaccharides representing the linkages cleaved by α-Glucosidase II in N-glycan biosynthesis. These (N1→3)-linked pseudodisaccharides were found to have some α-Glucosidase II inhibitory activity, while two other (N1→6)-linked valienamine pseudodisaccharides failed to inhibit the enzyme. |
| spellingShingle | Cumpstey, I Ramstadius, C Eszter Borbas, K Alonzi, D Butters, T Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis. |
| title | Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis. |
| title_full | Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis. |
| title_fullStr | Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis. |
| title_full_unstemmed | Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis. |
| title_short | Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis. |
| title_sort | synthesis and α glucosidase ii inhibitory activity of valienamine pseudodisaccharides relevant to n glycan biosynthesis |
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