Long-term treatment of depression with antidepressants: a systematic narrative review.
OBJECTIVE: To examine the available scientific evidence for answers to clinically relevant questions on the effectiveness and tolerability of antidepressant drugs (ADs) for the long-term treatment of depression. METHOD: The Cochrane Library was searched up to July 2006. When no complete Cochrane re...
| Huvudupphovsmän: | , , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
2007
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| _version_ | 1826290393917947904 |
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| author | Furukawa, T Cipriani, A Barbui, C Geddes, J |
| author_facet | Furukawa, T Cipriani, A Barbui, C Geddes, J |
| author_sort | Furukawa, T |
| collection | OXFORD |
| description | OBJECTIVE: To examine the available scientific evidence for answers to clinically relevant questions on the effectiveness and tolerability of antidepressant drugs (ADs) for the long-term treatment of depression. METHOD: The Cochrane Library was searched up to July 2006. When no complete Cochrane review was available, we looked in PubMed for relevant systematic reviews or individual randomized controlled trials. RESULTS: There was no good evidence that increasing the dosage of the initial AD is an effective strategy for patients with no, or partial, response to acute-phase treatment. There was no good evidence that switching between chemical classes of antidepressant was more effective than switching within a class. There was limited support from randomized trials for several augmentation strategies. There was good evidence for the effectiveness of long-term therapy to prevent relapse in patients who remitted after acute-phase treatment. The application of principles of evidence-based medicine suggested that thoughtful, individualized application of evidence is more appropriate than general statements. CONCLUSIONS: Available evidence provides some support for the effectiveness of several augmentation strategies in the management of patients with no, or partial, response to acute-phase treatment and for the individualized application of groupwise robust evidence for maintenance treatment with ADs to prevent relapses. However, side effects of these long-term treatments with ADs are poorly studied and reported. |
| first_indexed | 2024-03-07T02:43:31Z |
| format | Journal article |
| id | oxford-uuid:ab3f31ad-bc11-4b82-b05e-61b7e75b297d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:43:31Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:ab3f31ad-bc11-4b82-b05e-61b7e75b297d2022-03-27T03:20:47ZLong-term treatment of depression with antidepressants: a systematic narrative review.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ab3f31ad-bc11-4b82-b05e-61b7e75b297dEnglishSymplectic Elements at Oxford2007Furukawa, TCipriani, ABarbui, CGeddes, J OBJECTIVE: To examine the available scientific evidence for answers to clinically relevant questions on the effectiveness and tolerability of antidepressant drugs (ADs) for the long-term treatment of depression. METHOD: The Cochrane Library was searched up to July 2006. When no complete Cochrane review was available, we looked in PubMed for relevant systematic reviews or individual randomized controlled trials. RESULTS: There was no good evidence that increasing the dosage of the initial AD is an effective strategy for patients with no, or partial, response to acute-phase treatment. There was no good evidence that switching between chemical classes of antidepressant was more effective than switching within a class. There was limited support from randomized trials for several augmentation strategies. There was good evidence for the effectiveness of long-term therapy to prevent relapse in patients who remitted after acute-phase treatment. The application of principles of evidence-based medicine suggested that thoughtful, individualized application of evidence is more appropriate than general statements. CONCLUSIONS: Available evidence provides some support for the effectiveness of several augmentation strategies in the management of patients with no, or partial, response to acute-phase treatment and for the individualized application of groupwise robust evidence for maintenance treatment with ADs to prevent relapses. However, side effects of these long-term treatments with ADs are poorly studied and reported. |
| spellingShingle | Furukawa, T Cipriani, A Barbui, C Geddes, J Long-term treatment of depression with antidepressants: a systematic narrative review. |
| title | Long-term treatment of depression with antidepressants: a systematic narrative review. |
| title_full | Long-term treatment of depression with antidepressants: a systematic narrative review. |
| title_fullStr | Long-term treatment of depression with antidepressants: a systematic narrative review. |
| title_full_unstemmed | Long-term treatment of depression with antidepressants: a systematic narrative review. |
| title_short | Long-term treatment of depression with antidepressants: a systematic narrative review. |
| title_sort | long term treatment of depression with antidepressants a systematic narrative review |
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