A tidal breathing model of the inert gas sinewave technique for inhomogeneous lungs.
The tidal breathing model conservation of mass equations for the sinewave technique have been described for a homogeneous alveolar compartment by Gavaghan and Hahn, 1996 [Gavaghan, D.J., Hahn, C.E.W., 1996. A tidal breathing model of the forced inspired gas sinewave technique. Respir. Physiol. 106,...
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| Format: | Journal article |
| Language: | English |
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2001
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| _version_ | 1797088027127840768 |
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| author | Whiteley, J Gavaghan, D Hahn, C |
| author_facet | Whiteley, J Gavaghan, D Hahn, C |
| author_sort | Whiteley, J |
| collection | OXFORD |
| description | The tidal breathing model conservation of mass equations for the sinewave technique have been described for a homogeneous alveolar compartment by Gavaghan and Hahn, 1996 [Gavaghan, D.J., Hahn, C.E.W., 1996. A tidal breathing model of the forced inspired gas sinewave technique. Respir. Physiol. 106, 209-221]. We develop these equations first to a multi-discrete alveolar compartment lung model and then to a lung model with a continuous distribution of volume, ventilation and perfusion. The effect on the output parameters of a multi-compartment model is discussed, and the results are compared to those derived from the conventional continuous-ventilation model. Using the barely soluble gas argon as the tracer gas, an empirical index of alveolar inhomogeneity is presented which uses the end-expired and mixed-expired partial pressures on each breath. This index distinguishes between a narrow unimodal distribution of ventilation-volume, a wide unimodal distribution of ventilation-volume and a bimodal distribution of ventilation-volume. By using Monte Carlo simulations, this index is shown to be stable to experimental error of realistic magnitude. |
| first_indexed | 2024-03-07T02:44:01Z |
| format | Journal article |
| id | oxford-uuid:ab6bd866-8b53-4c77-8c26-5f4fd44124c6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:44:01Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:ab6bd866-8b53-4c77-8c26-5f4fd44124c62022-03-27T03:21:47ZA tidal breathing model of the inert gas sinewave technique for inhomogeneous lungs.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ab6bd866-8b53-4c77-8c26-5f4fd44124c6EnglishSymplectic Elements at Oxford2001Whiteley, JGavaghan, DHahn, CThe tidal breathing model conservation of mass equations for the sinewave technique have been described for a homogeneous alveolar compartment by Gavaghan and Hahn, 1996 [Gavaghan, D.J., Hahn, C.E.W., 1996. A tidal breathing model of the forced inspired gas sinewave technique. Respir. Physiol. 106, 209-221]. We develop these equations first to a multi-discrete alveolar compartment lung model and then to a lung model with a continuous distribution of volume, ventilation and perfusion. The effect on the output parameters of a multi-compartment model is discussed, and the results are compared to those derived from the conventional continuous-ventilation model. Using the barely soluble gas argon as the tracer gas, an empirical index of alveolar inhomogeneity is presented which uses the end-expired and mixed-expired partial pressures on each breath. This index distinguishes between a narrow unimodal distribution of ventilation-volume, a wide unimodal distribution of ventilation-volume and a bimodal distribution of ventilation-volume. By using Monte Carlo simulations, this index is shown to be stable to experimental error of realistic magnitude. |
| spellingShingle | Whiteley, J Gavaghan, D Hahn, C A tidal breathing model of the inert gas sinewave technique for inhomogeneous lungs. |
| title | A tidal breathing model of the inert gas sinewave technique for inhomogeneous lungs. |
| title_full | A tidal breathing model of the inert gas sinewave technique for inhomogeneous lungs. |
| title_fullStr | A tidal breathing model of the inert gas sinewave technique for inhomogeneous lungs. |
| title_full_unstemmed | A tidal breathing model of the inert gas sinewave technique for inhomogeneous lungs. |
| title_short | A tidal breathing model of the inert gas sinewave technique for inhomogeneous lungs. |
| title_sort | tidal breathing model of the inert gas sinewave technique for inhomogeneous lungs |
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