ARIEL and AMELIA: testing for an accumulation of rare variants using next-generation sequencing data.

ARIEL and AMELIA: testing for an accumulation of rare variants using next-generation sequencing data.

OBJECTIVES: There is increasing evidence that rare variants play a role in some complex traits, but their analysis is not straightforward. Locus-based tests become necessary due to low power in rare variant single-point association analyses. In addition, variant quality scores are available for sequ...

Bibliografske podrobnosti
Main Authors:	Asimit, J, Day-Williams, A, Morris, A, Zeggini, E
Format:	Journal article
Jezik:	English
Izdano:	2012

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