Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population.
Many genes have been shown to be involved in host susceptibility to the severe forms of Plasmodium falciparum malaria but it is likely that a large number of malaria-susceptibility genes remain to be determined. We conducted a large case-control study of children with the severe forms of this diseas...
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| Format: | Journal article |
| Language: | English |
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1998
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| _version_ | 1826290442038149120 |
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| author | Bellamy, R Kwiatkowski, D Hill, A |
| author_facet | Bellamy, R Kwiatkowski, D Hill, A |
| author_sort | Bellamy, R |
| collection | OXFORD |
| description | Many genes have been shown to be involved in host susceptibility to the severe forms of Plasmodium falciparum malaria but it is likely that a large number of malaria-susceptibility genes remain to be determined. We conducted a large case-control study of children with the severe forms of this disease-cerebral malaria and severe malarial anaemia--to attempt to identify these genes. Over 1200 children in The Gambia were typed for polymorphisms of the intercellular adhesion molecule 1 (ICAM-1), complement receptor 1 (CR-1) and interleukin 1 receptor antagonist (IL-IRA) genes. None of the polymorphisms typed was significantly associated with severe disease. These data differed significantly from the results of a previous study (Chi 2 = 8.81; P = 0.003) in which the ICAM-1 gene polymorphism was shown to be significantly associated with cerebral malaria in a case-control study of 547 subjects in Kenya. This suggests that there may be heterogeneity in genetic susceptibility to this condition between these 2 African populations. |
| first_indexed | 2024-03-07T02:44:15Z |
| format | Journal article |
| id | oxford-uuid:ab8023d8-708f-4886-aa3c-d4716015d4c9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:44:15Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:ab8023d8-708f-4886-aa3c-d4716015d4c92022-03-27T03:22:17ZAbsence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ab8023d8-708f-4886-aa3c-d4716015d4c9EnglishSymplectic Elements at Oxford1998Bellamy, RKwiatkowski, DHill, AMany genes have been shown to be involved in host susceptibility to the severe forms of Plasmodium falciparum malaria but it is likely that a large number of malaria-susceptibility genes remain to be determined. We conducted a large case-control study of children with the severe forms of this disease-cerebral malaria and severe malarial anaemia--to attempt to identify these genes. Over 1200 children in The Gambia were typed for polymorphisms of the intercellular adhesion molecule 1 (ICAM-1), complement receptor 1 (CR-1) and interleukin 1 receptor antagonist (IL-IRA) genes. None of the polymorphisms typed was significantly associated with severe disease. These data differed significantly from the results of a previous study (Chi 2 = 8.81; P = 0.003) in which the ICAM-1 gene polymorphism was shown to be significantly associated with cerebral malaria in a case-control study of 547 subjects in Kenya. This suggests that there may be heterogeneity in genetic susceptibility to this condition between these 2 African populations. |
| spellingShingle | Bellamy, R Kwiatkowski, D Hill, A Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population. |
| title | Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population. |
| title_full | Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population. |
| title_fullStr | Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population. |
| title_full_unstemmed | Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population. |
| title_short | Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population. |
| title_sort | absence of an association between intercellular adhesion molecule 1 complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a west african population |
| work_keys_str_mv | AT bellamyr absenceofanassociationbetweenintercellularadhesionmolecule1complementreceptor1andinterleukin1receptorantagonistgenepolymorphismsandseveremalariainawestafricanpopulation AT kwiatkowskid absenceofanassociationbetweenintercellularadhesionmolecule1complementreceptor1andinterleukin1receptorantagonistgenepolymorphismsandseveremalariainawestafricanpopulation AT hilla absenceofanassociationbetweenintercellularadhesionmolecule1complementreceptor1andinterleukin1receptorantagonistgenepolymorphismsandseveremalariainawestafricanpopulation |