The Digital Brain Bank, an open access platform for post-mortem imaging datasets
Post-mortem magnetic resonance imaging (MRI) provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), a data release pl...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
eLife Sciences Publications
2022
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| _version_ | 1797106723590242304 |
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| author | Tendler, BC Hanayik, T Ansorge, O Bangerter-Christensen, S Berns, GS Bertelsen, MF Bryant, KL Foxley, S Martijn van den Heuvel, P Howard, AFD Huszar, IN Khrapitchev, AA Leonte, A Manger, PR Menke, RAL Mollink, J Mortimer, D Pallebage-Gamarallage, M Roumazeilles, L Sallet, J Scholtens, LH Scott, C Smart, A Turner, MR Wang, C Jbabdi, S Mars, RB Miller, KL |
| author_facet | Tendler, BC Hanayik, T Ansorge, O Bangerter-Christensen, S Berns, GS Bertelsen, MF Bryant, KL Foxley, S Martijn van den Heuvel, P Howard, AFD Huszar, IN Khrapitchev, AA Leonte, A Manger, PR Menke, RAL Mollink, J Mortimer, D Pallebage-Gamarallage, M Roumazeilles, L Sallet, J Scholtens, LH Scott, C Smart, A Turner, MR Wang, C Jbabdi, S Mars, RB Miller, KL |
| author_sort | Tendler, BC |
| collection | OXFORD |
| description | Post-mortem magnetic resonance imaging (MRI) provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), a data release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes—Digital Neuroanatomist: datasets for detailed neuroanatomical investigations; Digital Brain Zoo: datasets for comparative neuroanatomy; and Digital Pathologist: datasets for neuropathology investigations. The first Digital Brain Bank data release includes 21 distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in fourteen nonhuman primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. The Digital Brain Bank is the culmination of our lab’s investment into post-mortem MRI methodology and MRI-microscopy analysis techniques. This manuscript provides a detailed overview of our work with post-mortem imaging to date, including the development of diffusion MRI methods to image large post-mortem samples, including whole, human brains. Taken together, the Digital Brain Bank provides cross-scale, cross-species datasets facilitating the incorporation of post-mortem data into neuroimaging studies.
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| first_indexed | 2024-03-07T07:06:33Z |
| format | Journal article |
| id | oxford-uuid:ab816b39-076c-4125-9514-6b8cf238cef5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:06:33Z |
| publishDate | 2022 |
| publisher | eLife Sciences Publications |
| record_format | dspace |
| spelling | oxford-uuid:ab816b39-076c-4125-9514-6b8cf238cef52022-05-06T11:47:49ZThe Digital Brain Bank, an open access platform for post-mortem imaging datasetsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ab816b39-076c-4125-9514-6b8cf238cef5EnglishSymplectic ElementseLife Sciences Publications2022Tendler, BCHanayik, TAnsorge, OBangerter-Christensen, SBerns, GSBertelsen, MFBryant, KLFoxley, SMartijn van den Heuvel, PHoward, AFDHuszar, INKhrapitchev, AALeonte, AManger, PRMenke, RALMollink, JMortimer, DPallebage-Gamarallage, MRoumazeilles, LSallet, JScholtens, LHScott, CSmart, ATurner, MRWang, CJbabdi, SMars, RBMiller, KLPost-mortem magnetic resonance imaging (MRI) provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), a data release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes—Digital Neuroanatomist: datasets for detailed neuroanatomical investigations; Digital Brain Zoo: datasets for comparative neuroanatomy; and Digital Pathologist: datasets for neuropathology investigations. The first Digital Brain Bank data release includes 21 distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in fourteen nonhuman primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. The Digital Brain Bank is the culmination of our lab’s investment into post-mortem MRI methodology and MRI-microscopy analysis techniques. This manuscript provides a detailed overview of our work with post-mortem imaging to date, including the development of diffusion MRI methods to image large post-mortem samples, including whole, human brains. Taken together, the Digital Brain Bank provides cross-scale, cross-species datasets facilitating the incorporation of post-mortem data into neuroimaging studies. |
| spellingShingle | Tendler, BC Hanayik, T Ansorge, O Bangerter-Christensen, S Berns, GS Bertelsen, MF Bryant, KL Foxley, S Martijn van den Heuvel, P Howard, AFD Huszar, IN Khrapitchev, AA Leonte, A Manger, PR Menke, RAL Mollink, J Mortimer, D Pallebage-Gamarallage, M Roumazeilles, L Sallet, J Scholtens, LH Scott, C Smart, A Turner, MR Wang, C Jbabdi, S Mars, RB Miller, KL The Digital Brain Bank, an open access platform for post-mortem imaging datasets |
| title | The Digital Brain Bank, an open access platform for post-mortem imaging datasets |
| title_full | The Digital Brain Bank, an open access platform for post-mortem imaging datasets |
| title_fullStr | The Digital Brain Bank, an open access platform for post-mortem imaging datasets |
| title_full_unstemmed | The Digital Brain Bank, an open access platform for post-mortem imaging datasets |
| title_short | The Digital Brain Bank, an open access platform for post-mortem imaging datasets |
| title_sort | digital brain bank an open access platform for post mortem imaging datasets |
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