Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia.
Computational modelling, combined with experimental investigations, is a powerful method for investigating complex cardiac electrophysiological behaviour. The use of rabbit-specific models, due to the similarities of cardiac electrophysiology in this species with human, is especially prevalent. In t...
| المؤلفون الرئيسيون: | , , , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
Elsevier
2016
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| _version_ | 1826290462212751360 |
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| author | Gemmell, P Burrage, K Rodríguez, B Quinn, T |
| author_facet | Gemmell, P Burrage, K Rodríguez, B Quinn, T |
| author_sort | Gemmell, P |
| collection | OXFORD |
| description | Computational modelling, combined with experimental investigations, is a powerful method for investigating complex cardiac electrophysiological behaviour. The use of rabbit-specific models, due to the similarities of cardiac electrophysiology in this species with human, is especially prevalent. In this paper, we first briefly review rabbit-specific computational modelling of ventricular cell electrophysiology, multi-cellular simulations including cellular heterogeneity, and acute ischemia. This mini-review is followed by an original computational investigation of variability in the electrophysiological response of two experimentally-calibrated populations of rabbit-specific ventricular myocyte action potential models to acute ischemia. We performed a systematic exploration of the response of the model populations to varying degrees of ischemia and individual ischemic parameters, to investigate their individual and combined effects on action potential duration and refractoriness. This revealed complex interactions between model population variability and ischemic factors, which combined to enhance variability during ischemia. This represents an important step towards an improved understanding of the role that physiological variability may play in electrophysiological alterations during acute ischemia. |
| first_indexed | 2024-03-07T02:44:33Z |
| format | Journal article |
| id | oxford-uuid:ab9966ba-a90b-4c03-978f-f8d15c958e4c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:44:33Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:ab9966ba-a90b-4c03-978f-f8d15c958e4c2022-03-27T03:23:03ZRabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ab9966ba-a90b-4c03-978f-f8d15c958e4cEnglishSymplectic Elements at OxfordElsevier2016Gemmell, PBurrage, KRodríguez, BQuinn, TComputational modelling, combined with experimental investigations, is a powerful method for investigating complex cardiac electrophysiological behaviour. The use of rabbit-specific models, due to the similarities of cardiac electrophysiology in this species with human, is especially prevalent. In this paper, we first briefly review rabbit-specific computational modelling of ventricular cell electrophysiology, multi-cellular simulations including cellular heterogeneity, and acute ischemia. This mini-review is followed by an original computational investigation of variability in the electrophysiological response of two experimentally-calibrated populations of rabbit-specific ventricular myocyte action potential models to acute ischemia. We performed a systematic exploration of the response of the model populations to varying degrees of ischemia and individual ischemic parameters, to investigate their individual and combined effects on action potential duration and refractoriness. This revealed complex interactions between model population variability and ischemic factors, which combined to enhance variability during ischemia. This represents an important step towards an improved understanding of the role that physiological variability may play in electrophysiological alterations during acute ischemia. |
| spellingShingle | Gemmell, P Burrage, K Rodríguez, B Quinn, T Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia. |
| title | Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia. |
| title_full | Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia. |
| title_fullStr | Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia. |
| title_full_unstemmed | Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia. |
| title_short | Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia. |
| title_sort | rabbit specific computational modelling of ventricular cell electrophysiology using populations of models to explore variability in the response to ischemia |
| work_keys_str_mv | AT gemmellp rabbitspecificcomputationalmodellingofventricularcellelectrophysiologyusingpopulationsofmodelstoexplorevariabilityintheresponsetoischemia AT burragek rabbitspecificcomputationalmodellingofventricularcellelectrophysiologyusingpopulationsofmodelstoexplorevariabilityintheresponsetoischemia AT rodriguezb rabbitspecificcomputationalmodellingofventricularcellelectrophysiologyusingpopulationsofmodelstoexplorevariabilityintheresponsetoischemia AT quinnt rabbitspecificcomputationalmodellingofventricularcellelectrophysiologyusingpopulationsofmodelstoexplorevariabilityintheresponsetoischemia |