T cell depletion by exposure to Campath-1G in vitro prevents graft-versus-host disease.

T cell depletion by exposure to Campath-1G in vitro prevents graft-versus-host disease.

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Campath-1G is an immunosuppressive monoclonal antibody directed against human lymphocytes. Its effectiveness in preventing graft-versus-host disease (GVHD) by simple opsonisation of bone marrow T-cells has been studied in 36 consecutive allografts: in 17 for leukaemia, one for essential thrombocytos...

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Bibliografiska uppgifter
Huvudupphovsmän:	Jacobs, P, Wood, L, Fullard, L, Waldmann, H, Hale, G
Materialtyp:	Journal article
Språk:	English
Publicerad:	1994

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T-CELL DEPLETION BY EXPOSURE TO CAMPATH-1G IN-VITRO PREVENTS GRAFT-VERSUS-HOST DISEASE
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Specificity of monoclonal antibody Campath-1.
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Availability of Campath-1 antibodies for bone marrow transplantation.
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The CAMPATH-1 antigen (CDw52).
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Campath-1G in vivo confers a low incidence of graft-versus-host disease associated with a high incidence of mixed chimaerism after bone marrow transplantation for severe aplastic anaemia using HLA-identical sibling donors.
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CAMPATH-1 antibodies in stem-cell transplantation.
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