ALIX regulates tumor-mediated immunosuppression by controlling EGFR activity and PD-L1 presentation

ALIX regulates tumor-mediated immunosuppression by controlling EGFR activity and PD-L1 presentation

The immunosuppressive transmembrane protein PD-L1 was shown to traffic via the multivesicular body (MVB) and to be released on exosomes. A high-content siRNA screen identified the endosomal sorting complexes required for transport (ESCRT)-associated protein ALIX as a regulator of both EGFR activity...

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Bibliographic Details
Main Authors: Monypenny, J, Milewicz, H, Flores-Borja, F, Weitsman, G, Cheung, A, Chowdhury, R, Burgoyne, T, Arulappu, A, Lawler, K, Barber, P, Vicencio, J, Keppler, M, Wulaningsih, W, Davidson, S, Fraternali, F, Woodman, N, Turmaine, M, Gillett, C, Franz, D, Quezada, S, Futter, C, Von Kriegsheim, A, Kolch, W, Vojnovic, B, Carlton, J, Ng, T
Format: Journal article
Published: Elsevier 2018

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