C-C Bond Activation of a Cyclopropyl Phosphine: Isolation and Reactivity of a Tetrameric Rhodacyclobutane
Reaction of the functionalized phosphine P tBu 2CH 2(C 3H 5) with [Rh(C 8H 14) 2Cl]...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2010
|
| _version_ | 1797088135291600896 |
|---|---|
| author | Chaplin, AB Weller, A |
| author_facet | Chaplin, AB Weller, A |
| author_sort | Chaplin, AB |
| collection | OXFORD |
| description | Reaction of the functionalized phosphine P tBu 2CH 2(C 3H 5) with [Rh(C 8H 14) 2Cl] 2 (C 8H 14 = cis-cyclooctene) resulted in selective C-C bond activation of the cyclopropyl group and formation of a tetrameric rhodacyclobutane, [RhCl(- 3-P tBu 2CH 2CH(CH 2) 2)] 4, which was characterized in the solid state by X-ray crystallography. This complex acts as a latent source of the [Rh(- 3-P tBu 2CH 2CH(CH 2) 2)] + fragment, forming a range of new complexes by salt metathesis with NaCp, [RhCp(- 3-P tBu 2CH 2CH(CH 2) 2)], chloride abstraction in the presence of arenes, [Rh(- 6-arene)(- 3-P tBu 2CH 2CH(CH 2) 2)][BAr F4] [arene = C 6H 5F, C 6H 3Me 3; Ar F = 3,5-C 6H 3(CF 3) 2], or fragmentation by addition of phosphine ligands, trans-[RhCl(PR 3)(- 3-P tBu 2CH 2CH(CH 2) 2)] (R = iBu, Cy). In contrast, reaction with carbon monoxide results in the reductive elimination of the tethered cyclopropane, demonstrating reversible C-C bond activation, and formation of cis-[RhCl(CO) 2(P tBuCH 2(C 3H 5))]. These complexes were characterized in solution by NMR spectroscopy and in the solid state by X-ray diffraction. Chloride abstraction from [RhCl(P iBu 3)(- 3-P tBu 2CH 2CH(CH 2) 2)] resulted in the regioselective isomerization of the tethered cyclopropane to a terminal alkene, viz., the formally 14-electron complex [Rh(P iBu 3)(- 3-P tBu 2CH 2CH 2CH - CH 2)][BAr F4], notable for the presence of a strong agostic interaction with a phosphine iBu substituent, apparent both from the solid-state structure and in solution by 1H NMR spectroscopy. Addition of hydrogen to this complex resulted in hydrogenation of the alkene and formation of [Rh(H) 2(P iBu 3)(P tBu 2nBu)][BAr F4]. These steps overall correspond to selective C-C bond functionalization (hydrogenation) of the tethered cyclopropane and are of direct significance to a related catalytic process [J. Am. Chem. Soc. 2003, 125, 886] and, more generally, to the rhodium-mediated transformation of alkanes. © 2010 American Chemical Society. |
| first_indexed | 2024-03-07T02:45:36Z |
| format | Journal article |
| id | oxford-uuid:abf63f16-22db-4907-ad67-ed3f588d0fd0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:45:36Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:abf63f16-22db-4907-ad67-ed3f588d0fd02022-03-27T03:25:26ZC-C Bond Activation of a Cyclopropyl Phosphine: Isolation and Reactivity of a Tetrameric RhodacyclobutaneJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:abf63f16-22db-4907-ad67-ed3f588d0fd0EnglishSymplectic Elements at Oxford2010Chaplin, ABWeller, AReaction of the functionalized phosphine P tBu 2CH 2(C 3H 5) with [Rh(C 8H 14) 2Cl] 2 (C 8H 14 = cis-cyclooctene) resulted in selective C-C bond activation of the cyclopropyl group and formation of a tetrameric rhodacyclobutane, [RhCl(- 3-P tBu 2CH 2CH(CH 2) 2)] 4, which was characterized in the solid state by X-ray crystallography. This complex acts as a latent source of the [Rh(- 3-P tBu 2CH 2CH(CH 2) 2)] + fragment, forming a range of new complexes by salt metathesis with NaCp, [RhCp(- 3-P tBu 2CH 2CH(CH 2) 2)], chloride abstraction in the presence of arenes, [Rh(- 6-arene)(- 3-P tBu 2CH 2CH(CH 2) 2)][BAr F4] [arene = C 6H 5F, C 6H 3Me 3; Ar F = 3,5-C 6H 3(CF 3) 2], or fragmentation by addition of phosphine ligands, trans-[RhCl(PR 3)(- 3-P tBu 2CH 2CH(CH 2) 2)] (R = iBu, Cy). In contrast, reaction with carbon monoxide results in the reductive elimination of the tethered cyclopropane, demonstrating reversible C-C bond activation, and formation of cis-[RhCl(CO) 2(P tBuCH 2(C 3H 5))]. These complexes were characterized in solution by NMR spectroscopy and in the solid state by X-ray diffraction. Chloride abstraction from [RhCl(P iBu 3)(- 3-P tBu 2CH 2CH(CH 2) 2)] resulted in the regioselective isomerization of the tethered cyclopropane to a terminal alkene, viz., the formally 14-electron complex [Rh(P iBu 3)(- 3-P tBu 2CH 2CH 2CH - CH 2)][BAr F4], notable for the presence of a strong agostic interaction with a phosphine iBu substituent, apparent both from the solid-state structure and in solution by 1H NMR spectroscopy. Addition of hydrogen to this complex resulted in hydrogenation of the alkene and formation of [Rh(H) 2(P iBu 3)(P tBu 2nBu)][BAr F4]. These steps overall correspond to selective C-C bond functionalization (hydrogenation) of the tethered cyclopropane and are of direct significance to a related catalytic process [J. Am. Chem. Soc. 2003, 125, 886] and, more generally, to the rhodium-mediated transformation of alkanes. © 2010 American Chemical Society. |
| spellingShingle | Chaplin, AB Weller, A C-C Bond Activation of a Cyclopropyl Phosphine: Isolation and Reactivity of a Tetrameric Rhodacyclobutane |
| title | C-C Bond Activation of a Cyclopropyl Phosphine: Isolation and Reactivity of a Tetrameric Rhodacyclobutane |
| title_full | C-C Bond Activation of a Cyclopropyl Phosphine: Isolation and Reactivity of a Tetrameric Rhodacyclobutane |
| title_fullStr | C-C Bond Activation of a Cyclopropyl Phosphine: Isolation and Reactivity of a Tetrameric Rhodacyclobutane |
| title_full_unstemmed | C-C Bond Activation of a Cyclopropyl Phosphine: Isolation and Reactivity of a Tetrameric Rhodacyclobutane |
| title_short | C-C Bond Activation of a Cyclopropyl Phosphine: Isolation and Reactivity of a Tetrameric Rhodacyclobutane |
| title_sort | c c bond activation of a cyclopropyl phosphine isolation and reactivity of a tetrameric rhodacyclobutane |
| work_keys_str_mv | AT chaplinab ccbondactivationofacyclopropylphosphineisolationandreactivityofatetramericrhodacyclobutane AT wellera ccbondactivationofacyclopropylphosphineisolationandreactivityofatetramericrhodacyclobutane |