A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.

A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.

Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain and#8764;25% of the heritability of the phenotypes. To date, no unbiased screen for gene-environment interactions for circulating lipids has been reported. We screened for var...

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Main Authors: Surakka, I, Isaacs, A, Karssen, L, Laurila, P, Middelberg, R, Tikkanen, E, Ried, J, Lamina, C, Mangino, M, Igl, W, Hottenga, J, Lagou, V, van der Harst, P, Mateo Leach, I, Esko, T, Kutalik, Z, Wainwright, N, Struchalin, M, Sarin, A, Kangas, A, Viikari, J, Perola, M, Rantanen, T, Petersen, A, Soininen, P, Johansson, A, Soranzo, N, Heath, A, Papamarkou, T, Prokopenko, I, Tönjes, A, Kronenberg, F, Döring, A, Rivadeneira, F, Montgomery, G, Whitfield, J, Kähönen, M, Lehtimäki, T, Freimer, N, Willemsen, G, de Geus, E, Palotie, A, Sandhu, MS, Waterworth, D, Metspalu, A, Stumvoll, M, Uitterlinden, A, Jula, A, Navis, G, Wijmenga, C, Wolffenbuttel, B, Taskinen, MR, Ala-Korpela, M, Kaprio, J, Kyvik, K, Boomsma, D, Pedersen, N, Gyllensten, U, Wilson, J, Rudan, I, Campbell, H, Pramstaller, P, Spector, T, Witteman, J, Eriksson, J, Salomaa, V, Oostra, B, Raitakari, O, Wichmann, H, Gieger, C, Järvelin, MR, Martin, N, Hofman, A, McCarthy, M, Peltonen, L, van Duijn, C, Aulchenko, Y, Ripatti, S
Format: Journal article
Language:English
Published: Public Library of Science 2011

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