MAITs and their mates: "Innate-like" behaviors in conventional and unconventional T cells
Most CD4 and CD8 T cells are restricted by conventional major histocompatibility complex (MHC) molecules and mount TCR-dependent adaptive immune responses. In contrast, MAIT, iNKT, and certain γδ TCR bearing cells are characterized by their abilities to recognize antigens presented by unconventional...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Oxford University Press
2023
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| _version_ | 1797111514284425216 |
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| author | Hackstein, C-P Klenerman, P |
| author_facet | Hackstein, C-P Klenerman, P |
| author_sort | Hackstein, C-P |
| collection | OXFORD |
| description | Most CD4 and CD8 T cells are restricted by conventional major histocompatibility complex (MHC) molecules and mount TCR-dependent adaptive immune responses. In contrast, MAIT, iNKT, and certain γδ TCR bearing cells are characterized by their abilities to recognize antigens presented by unconventional antigen-presenting molecules and to mount cytokine-mediated TCR-independent responses in an "innate-like" manner. In addition, several more diverse T-cell subsets have been described that in a similar manner are restricted by unconventional antigen-presenting molecules but mainly depend on their TCRs for activation. Vice versa, innate-like behaviour was reported in defined subpopulations of conventional T cells, particularly in barrier sites, showing that these two features are not necessarily linked. The abilities to recognize antigens presented by unconventional antigen-presenting molecules or to mount TCR-independent responses creates unique niches for these T cells and is linked to wide range of functional capabilities. This is especially exemplified by unconventional and innate-like T cells present at barrier sites where they are involved in pathogen defense, tissue homeostasis as well as in pathologic processes. |
| first_indexed | 2024-03-07T08:09:57Z |
| format | Journal article |
| id | oxford-uuid:ac171449-3f7e-432f-a215-a3a5894a626c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:09:57Z |
| publishDate | 2023 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:ac171449-3f7e-432f-a215-a3a5894a626c2023-11-20T16:45:17ZMAITs and their mates: "Innate-like" behaviors in conventional and unconventional T cellsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ac171449-3f7e-432f-a215-a3a5894a626cEnglishSymplectic ElementsOxford University Press2023Hackstein, C-PKlenerman, PMost CD4 and CD8 T cells are restricted by conventional major histocompatibility complex (MHC) molecules and mount TCR-dependent adaptive immune responses. In contrast, MAIT, iNKT, and certain γδ TCR bearing cells are characterized by their abilities to recognize antigens presented by unconventional antigen-presenting molecules and to mount cytokine-mediated TCR-independent responses in an "innate-like" manner. In addition, several more diverse T-cell subsets have been described that in a similar manner are restricted by unconventional antigen-presenting molecules but mainly depend on their TCRs for activation. Vice versa, innate-like behaviour was reported in defined subpopulations of conventional T cells, particularly in barrier sites, showing that these two features are not necessarily linked. The abilities to recognize antigens presented by unconventional antigen-presenting molecules or to mount TCR-independent responses creates unique niches for these T cells and is linked to wide range of functional capabilities. This is especially exemplified by unconventional and innate-like T cells present at barrier sites where they are involved in pathogen defense, tissue homeostasis as well as in pathologic processes. |
| spellingShingle | Hackstein, C-P Klenerman, P MAITs and their mates: "Innate-like" behaviors in conventional and unconventional T cells |
| title | MAITs and their mates: "Innate-like" behaviors in conventional and unconventional T cells |
| title_full | MAITs and their mates: "Innate-like" behaviors in conventional and unconventional T cells |
| title_fullStr | MAITs and their mates: "Innate-like" behaviors in conventional and unconventional T cells |
| title_full_unstemmed | MAITs and their mates: "Innate-like" behaviors in conventional and unconventional T cells |
| title_short | MAITs and their mates: "Innate-like" behaviors in conventional and unconventional T cells |
| title_sort | maits and their mates innate like behaviors in conventional and unconventional t cells |
| work_keys_str_mv | AT hacksteincp maitsandtheirmatesinnatelikebehaviorsinconventionalandunconventionaltcells AT klenermanp maitsandtheirmatesinnatelikebehaviorsinconventionalandunconventionaltcells |