Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo.
Understanding the mechanisms that coordinate the orientation of cell division planes during embryogenesis and morphogenesis is a fundamental problem in developmental biology. Here we show that the orphan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishme...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1797088189797629952 |
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| author | Langenhan, T Prömel, S Mestek, L Esmaeili, B Waller-Evans, H Hennig, C Kohara, Y Avery, L Vakonakis, I Schnabel, R Russ, A |
| author_facet | Langenhan, T Prömel, S Mestek, L Esmaeili, B Waller-Evans, H Hennig, C Kohara, Y Avery, L Vakonakis, I Schnabel, R Russ, A |
| author_sort | Langenhan, T |
| collection | OXFORD |
| description | Understanding the mechanisms that coordinate the orientation of cell division planes during embryogenesis and morphogenesis is a fundamental problem in developmental biology. Here we show that the orphan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishment of tissue polarity in the C. elegans embryo. We provide evidence that lat-1 is required for the alignment of cell division planes to the anterior-posterior axis and acts in parallel to known polarity and morphogenesis signals. lat-1 is a member of the Adhesion-GPCR protein family and is structurally related to flamingo/CELSR, an essential component of the planar cell polarity pathway. We dissect the molecular requirements of lat-1 signaling and implicate lat-1 in an anterior-posterior tissue polarity pathway in the premorphogenesis stage of C. elegans development. |
| first_indexed | 2024-03-07T02:46:25Z |
| format | Journal article |
| id | oxford-uuid:ac37ce10-5b78-4679-986c-bb655985b046 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:46:25Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:ac37ce10-5b78-4679-986c-bb655985b0462022-03-27T03:27:15ZLatrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ac37ce10-5b78-4679-986c-bb655985b046EnglishSymplectic Elements at Oxford2009Langenhan, TPrömel, SMestek, LEsmaeili, BWaller-Evans, HHennig, CKohara, YAvery, LVakonakis, ISchnabel, RRuss, AUnderstanding the mechanisms that coordinate the orientation of cell division planes during embryogenesis and morphogenesis is a fundamental problem in developmental biology. Here we show that the orphan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishment of tissue polarity in the C. elegans embryo. We provide evidence that lat-1 is required for the alignment of cell division planes to the anterior-posterior axis and acts in parallel to known polarity and morphogenesis signals. lat-1 is a member of the Adhesion-GPCR protein family and is structurally related to flamingo/CELSR, an essential component of the planar cell polarity pathway. We dissect the molecular requirements of lat-1 signaling and implicate lat-1 in an anterior-posterior tissue polarity pathway in the premorphogenesis stage of C. elegans development. |
| spellingShingle | Langenhan, T Prömel, S Mestek, L Esmaeili, B Waller-Evans, H Hennig, C Kohara, Y Avery, L Vakonakis, I Schnabel, R Russ, A Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. |
| title | Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. |
| title_full | Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. |
| title_fullStr | Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. |
| title_full_unstemmed | Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. |
| title_short | Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. |
| title_sort | latrophilin signaling links anterior posterior tissue polarity and oriented cell divisions in the c elegans embryo |
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