Early acquisition of cytolytic function and transcriptional changes in a primary CD8+ T-cell response in vivo.
Functional studies show that programming of CD8+ T cells occurs early after initial antigen encounter within as little as 2 hours. To define the molecular basis of these events, we transferred TCR transgenic T cells from F5 Rag-/- mice into naive recipients and stimulated them with recombinant vacci...
Автори: | Chiu, C, Heaps, A, Cerundolo, V, Mcmichael, A, Bangham, C, Callan, M |
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Формат: | Journal article |
Мова: | English |
Опубліковано: |
2007
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