Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

<p><strong>Background:</strong> Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan-dioxygenase (TDO) are enzymes catabolizing the essential amino acid tryptophan into kynurenine. Expression of these enzymes is frequently observed in advanced-stage cancers and is associated with po...

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Những tác giả chính:	Solvay, M, Holfelder, P, Klaessens, S, Pilotte, L, Stroobant, V, Lamy, J, Naulaerts, S, Spillier, Q, Frédérick, R, De Plaen, E, Sers, C, Opitz, CA, Van den Eynde, BJ, Zhu, J
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	BMJ Publishing Group 2023

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

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