Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered.
CTLA-4 is a critical negative regulator of T cell responses and CTLA-4-deficient (CTLA-4(-/-)) mice die of a lymphproliferative disease. Nevertheless, RAG-2-deficient mice reconstituted with a mixture of CTLA-4(-/-) and normal (CTLA-4(+/+)) bone marrow survive in the absence of any signs of disease,...
Main Authors: | Bachmann, M, Gallimore, A, Jones, E, Ecabert, B, Acha-Orbea, H, Kopf, M |
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Format: | Journal article |
Language: | English |
Published: |
2001
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