Studies on human cancer variant and mycobacterial isocitrate dehydrogenases
<p>Mutations in human IDH genes occur in cancer and result in active site IDH variants with a gain-of-function ability to reduce the normal 2-oxoglutarate (2-OG) product of IDH catalysis to 2-hydroxyglutarate (2-HG). As reviewed in Chapter 1, elevated 2-HG levels are proposed to promote tumori...
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| Formaat: | Thesis |
| Taal: | English |
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2021
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