An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress

An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress

TDP-43 pathology is a key feature of amyotrophic lateral sclerosis (ALS), but the mechanisms linking TDP-43 to altered cellular function and neurodegeneration remain unclear. We have recently described a mouse model in which human wild-type or mutant TDP-43 are expressed at low levels and where alte...

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Bibliographic Details
Main Authors:	Feneberg, E, Gordon, D, Thompson, AG, Finelli, MJ, Dafinca, R, Candalija, A, Charles, PD, Mäger, I, Wood, MJ, Fischer, R, Kessler, BM, Gray, E, Turner, MR, Talbot, K
Format:	Journal article
Language:	English
Published:	Elsevier 2020

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