P-233: SCALOP-2: A multi-centre randomised study of induction chemotherapy followed by capecitabine (+/- nelfinavir) with high or standard dose radiotherapy for locally advanced non-metastatic pancreatic cancer

hemotherapy followed by consolidation chemoradiotherapy (CRT) is a treatment option for locally advanced non-metastatic pancreatic cancer (LAPC), but outcome remains poor. The SCALOP trial identified a feasible, safe, and effective CRT regimen for LAPC: capecitabine (830mg/m2 oral bd) as radiosensit...

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Manylion Llyfryddiaeth
Prif Awduron: Virdee, P, Shaw, R, Strauss, V, Hamill, C, Hurt, C, Gwynne, S, Corrie, P, Bridgewater, J, Parsons, P, Tranter, B, Sebag-Montefiore, D, Chu, K, Radhakrishna, G, Hawkins, M, O'Neill, E, Campbell, S, Love, S, Maughan, T, Mukherjee, S
Fformat: Conference item
Cyhoeddwyd: Oxford University Press 2017
Disgrifiad
Crynodeb:hemotherapy followed by consolidation chemoradiotherapy (CRT) is a treatment option for locally advanced non-metastatic pancreatic cancer (LAPC), but outcome remains poor. The SCALOP trial identified a feasible, safe, and effective CRT regimen for LAPC: capecitabine (830mg/m2 oral bd) as radiosensitisation + 50.4Gy in 28 fractions. The two-stage SCALOP-2 trial aims to improve this regimen by increasing radiotherapy dose intensity and adding nelfinavir as an additional radiosensitising AKT inhibitor.