A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma.

A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma.

RASSF1A (Ras association domain containing family 1A), a tumor suppressor gene that is frequently inactivated in human cancers, is phosphorylated by ataxia telangiectasia mutated (ATM) on Ser131 upon DNA damage, leading to activation of a p73-dependent apoptotic response. A single-nucleotide polymor...

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Bibliographic Details
Main Authors:	Yee, K, Grochola, L, Hamilton, G, Grawenda, A, Bond, E, Taubert, H, Wurl, P, Bond, G, O'Neill, E
Format:	Journal article
Language:	English
Published:	2012

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