High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes.
OBJECTIVE: Maturity-onset diabetes of the young (MODY) as a result of mutations in hepatocyte nuclear factor 1-α (HNF1A) is often misdiagnosed as type 1 diabetes or type 2 diabetes. Recent work has shown that high-sensitivity C-reactive protein (hs-CRP) levels are lower in HNF1A-MODY than type 1 dia...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2011
|
| _version_ | 1826290675725893632 |
|---|---|
| author | McDonald, T Shields, B Lawry, J Owen, K Gloyn, A Ellard, S Hattersley, A |
| author_facet | McDonald, T Shields, B Lawry, J Owen, K Gloyn, A Ellard, S Hattersley, A |
| author_sort | McDonald, T |
| collection | OXFORD |
| description | OBJECTIVE: Maturity-onset diabetes of the young (MODY) as a result of mutations in hepatocyte nuclear factor 1-α (HNF1A) is often misdiagnosed as type 1 diabetes or type 2 diabetes. Recent work has shown that high-sensitivity C-reactive protein (hs-CRP) levels are lower in HNF1A-MODY than type 1 diabetes, type 2 diabetes, or glucokinase (GCK)-MODY. We aim to replicate these findings in larger numbers and other MODY subtypes. RESEARCH DESIGN AND METHODS: hs-CRP levels were assessed in 750 patients (220 HNF1A, 245 GCK, 54 HNF4-α [HNF4A], 21 HNF1-β (HNF1B), 53 type 1 diabetes, and 157 type 2 diabetes). RESULTS: hs-CRP was lower in HNF1A-MODY (median [IQR] 0.3 [0.1-0.6] mg/L) than type 2 diabetes (1.40 [0.60-3.45] mg/L; P < 0.001) and type 1 diabetes (1.10 [0.50-1.85] mg/L; P < 0.001), HNF4A-MODY (1.45 [0.46-2.88] mg/L; P < 0.001), GCK-MODY (0.60 [0.30-1.80] mg/L; P < 0.001), and HNF1B-MODY (0.60 [0.10-2.8] mg/L; P = 0.07). hs-CRP discriminated HNF1A-MODY from type 2 diabetes with hs-CRP <0.75 mg/L showing 79% sensitivity and 70% specificity (receiver operating characteristic area under the curve = 0.84). CONCLUSIONS: hs-CRP levels are lower in HNF1A-MODY than other forms of diabetes and may be used as a biomarker to select patients for diagnostic HNF1A genetic testing. |
| first_indexed | 2024-03-07T02:47:49Z |
| format | Journal article |
| id | oxford-uuid:aca141f4-dbef-41d0-b049-3761442fa112 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:47:49Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:aca141f4-dbef-41d0-b049-3761442fa1122022-03-27T03:30:16ZHigh-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:aca141f4-dbef-41d0-b049-3761442fa112EnglishSymplectic Elements at Oxford2011McDonald, TShields, BLawry, JOwen, KGloyn, AEllard, SHattersley, AOBJECTIVE: Maturity-onset diabetes of the young (MODY) as a result of mutations in hepatocyte nuclear factor 1-α (HNF1A) is often misdiagnosed as type 1 diabetes or type 2 diabetes. Recent work has shown that high-sensitivity C-reactive protein (hs-CRP) levels are lower in HNF1A-MODY than type 1 diabetes, type 2 diabetes, or glucokinase (GCK)-MODY. We aim to replicate these findings in larger numbers and other MODY subtypes. RESEARCH DESIGN AND METHODS: hs-CRP levels were assessed in 750 patients (220 HNF1A, 245 GCK, 54 HNF4-α [HNF4A], 21 HNF1-β (HNF1B), 53 type 1 diabetes, and 157 type 2 diabetes). RESULTS: hs-CRP was lower in HNF1A-MODY (median [IQR] 0.3 [0.1-0.6] mg/L) than type 2 diabetes (1.40 [0.60-3.45] mg/L; P < 0.001) and type 1 diabetes (1.10 [0.50-1.85] mg/L; P < 0.001), HNF4A-MODY (1.45 [0.46-2.88] mg/L; P < 0.001), GCK-MODY (0.60 [0.30-1.80] mg/L; P < 0.001), and HNF1B-MODY (0.60 [0.10-2.8] mg/L; P = 0.07). hs-CRP discriminated HNF1A-MODY from type 2 diabetes with hs-CRP <0.75 mg/L showing 79% sensitivity and 70% specificity (receiver operating characteristic area under the curve = 0.84). CONCLUSIONS: hs-CRP levels are lower in HNF1A-MODY than other forms of diabetes and may be used as a biomarker to select patients for diagnostic HNF1A genetic testing. |
| spellingShingle | McDonald, T Shields, B Lawry, J Owen, K Gloyn, A Ellard, S Hattersley, A High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes. |
| title | High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes. |
| title_full | High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes. |
| title_fullStr | High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes. |
| title_full_unstemmed | High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes. |
| title_short | High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes. |
| title_sort | high sensitivity crp discriminates hnf1a mody from other subtypes of diabetes |
| work_keys_str_mv | AT mcdonaldt highsensitivitycrpdiscriminateshnf1amodyfromothersubtypesofdiabetes AT shieldsb highsensitivitycrpdiscriminateshnf1amodyfromothersubtypesofdiabetes AT lawryj highsensitivitycrpdiscriminateshnf1amodyfromothersubtypesofdiabetes AT owenk highsensitivitycrpdiscriminateshnf1amodyfromothersubtypesofdiabetes AT gloyna highsensitivitycrpdiscriminateshnf1amodyfromothersubtypesofdiabetes AT ellards highsensitivitycrpdiscriminateshnf1amodyfromothersubtypesofdiabetes AT hattersleya highsensitivitycrpdiscriminateshnf1amodyfromothersubtypesofdiabetes |