Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy.

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy.

We previously demonstrated that proto-oncogene Fyn decreased energy expenditure and increased metabolic phenotypes. Also Fyn decreased autophagy-mediated muscle mass by directly inhibiting LKB1 and stimulating STAT3 activities, respectively. AMPK, a downstream target of LKB1, was recently identified...

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Bibliographic Details
Main Authors:	Yamada, E, Okada, S, Bastie, C, Vatish, M, Nakajima, Y, Shibusawa, R, Ozawa, A, Pessin, J, Yamada, M
Format:	Journal article
Language:	English
Published:	Impact Journals 2016

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