Directional porin binding of intrinsically disordered protein sequences promotes colicin epitope display in the bacterial periplasm

Directional porin binding of intrinsically disordered protein sequences promotes colicin epitope display in the bacterial periplasm

Protein bacteriocins are potent narrow spectrum antibiotics that exploit outer membrane porins to kill bacteria by poorly understood mechanisms. Here, we determine how colicins, bacteriocins specific for Escherichia coli, engage the trimeric porin OmpF to initiate toxin entry. The N-terminal ∼80 res...

书目详细资料
Main Authors:	Housden, NG, Rassam, P, Lee, S, Samsudin, F, Kaminska, R, Sharp, C, Goult, JD, Francis, M-L, Khalid, S, Bayley, H, Kleanthous, C
格式:	Journal article
语言:	English
出版:	American Chemical Society 2018

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