Gluteal muscle atrophy and increased intramuscular lipid concentration are not mitigated by daily artificial gravity following 60-day head-down tilt bed rest
Exposure to spaceflight and head-down tilt (HDT) bed rest leads to decreases in the mass of the gluteal muscle. Preliminary results have suggested that interventions, such as artificial gravity (AG), can partially mitigate some of the physiological adaptations induced by HDT bed rest. However, its e...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Frontiers
2021
|
| _version_ | 1797088333429473280 |
|---|---|
| author | Tran, V De Martino, E Hides, J Cable, G Elliott, JM Hoggarth, M Zange, J Lindsay, K Debuse, D Winnard, A Beard, D Cook, JA Salomoni, SE Weber, T Scott, J Hodges, PW Caplan, N |
| author_facet | Tran, V De Martino, E Hides, J Cable, G Elliott, JM Hoggarth, M Zange, J Lindsay, K Debuse, D Winnard, A Beard, D Cook, JA Salomoni, SE Weber, T Scott, J Hodges, PW Caplan, N |
| author_sort | Tran, V |
| collection | OXFORD |
| description | Exposure to spaceflight and head-down tilt (HDT) bed rest leads to decreases in the mass of the gluteal muscle. Preliminary results have suggested that interventions, such as artificial gravity (AG), can partially mitigate some of the physiological adaptations induced by HDT bed rest. However, its effect on the gluteal muscles is currently unknown. This study investigated the effects of daily AG on the gluteal muscles during 60-day HDT bed rest. Twenty-four healthy individuals participated in the study: eight received 30 min of continuous AG; eight received 6 × 5 min of AG, interspersed with rest periods; eight belonged to a control group. T1-weighted Dixon magnetic resonance imaging of the hip region was conducted at baseline and day 59 of HDT bed rest to establish changes in volumes and intramuscular lipid concentration (ILC). Results showed that, across groups, muscle volumes decreased by 9.2% for gluteus maximus (GMAX), 8.0% for gluteus medius (GMED), and 10.5% for gluteus minimus after 59-day HDT bed rest (all p < 0.005). The ILC increased by 1.3% for GMAX and 0.5% for GMED (both p < 0.05). Neither of the AG protocols mitigated deconditioning of the gluteal muscles. Whereas all gluteal muscles atrophied, the ratio of lipids to intramuscular water increased only in GMAX and GMED muscles. These changes could impair the function of the hip joint and increased the risk of falls. The deconditioning of the gluteal muscles in space may negatively impact the hip joint stability of astronauts when reexpose to terrestrial gravity. |
| first_indexed | 2024-03-07T02:48:31Z |
| format | Journal article |
| id | oxford-uuid:acdd046f-3780-42db-8c74-fdf3d9d1dcf0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:48:31Z |
| publishDate | 2021 |
| publisher | Frontiers |
| record_format | dspace |
| spelling | oxford-uuid:acdd046f-3780-42db-8c74-fdf3d9d1dcf02022-03-27T03:31:50ZGluteal muscle atrophy and increased intramuscular lipid concentration are not mitigated by daily artificial gravity following 60-day head-down tilt bed restJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:acdd046f-3780-42db-8c74-fdf3d9d1dcf0EnglishSymplectic ElementsFrontiers2021Tran, VDe Martino, EHides, JCable, GElliott, JMHoggarth, MZange, JLindsay, KDebuse, DWinnard, ABeard, DCook, JASalomoni, SEWeber, TScott, JHodges, PWCaplan, NExposure to spaceflight and head-down tilt (HDT) bed rest leads to decreases in the mass of the gluteal muscle. Preliminary results have suggested that interventions, such as artificial gravity (AG), can partially mitigate some of the physiological adaptations induced by HDT bed rest. However, its effect on the gluteal muscles is currently unknown. This study investigated the effects of daily AG on the gluteal muscles during 60-day HDT bed rest. Twenty-four healthy individuals participated in the study: eight received 30 min of continuous AG; eight received 6 × 5 min of AG, interspersed with rest periods; eight belonged to a control group. T1-weighted Dixon magnetic resonance imaging of the hip region was conducted at baseline and day 59 of HDT bed rest to establish changes in volumes and intramuscular lipid concentration (ILC). Results showed that, across groups, muscle volumes decreased by 9.2% for gluteus maximus (GMAX), 8.0% for gluteus medius (GMED), and 10.5% for gluteus minimus after 59-day HDT bed rest (all p < 0.005). The ILC increased by 1.3% for GMAX and 0.5% for GMED (both p < 0.05). Neither of the AG protocols mitigated deconditioning of the gluteal muscles. Whereas all gluteal muscles atrophied, the ratio of lipids to intramuscular water increased only in GMAX and GMED muscles. These changes could impair the function of the hip joint and increased the risk of falls. The deconditioning of the gluteal muscles in space may negatively impact the hip joint stability of astronauts when reexpose to terrestrial gravity. |
| spellingShingle | Tran, V De Martino, E Hides, J Cable, G Elliott, JM Hoggarth, M Zange, J Lindsay, K Debuse, D Winnard, A Beard, D Cook, JA Salomoni, SE Weber, T Scott, J Hodges, PW Caplan, N Gluteal muscle atrophy and increased intramuscular lipid concentration are not mitigated by daily artificial gravity following 60-day head-down tilt bed rest |
| title | Gluteal muscle atrophy and increased intramuscular lipid concentration are not mitigated by daily artificial gravity following 60-day head-down tilt bed rest |
| title_full | Gluteal muscle atrophy and increased intramuscular lipid concentration are not mitigated by daily artificial gravity following 60-day head-down tilt bed rest |
| title_fullStr | Gluteal muscle atrophy and increased intramuscular lipid concentration are not mitigated by daily artificial gravity following 60-day head-down tilt bed rest |
| title_full_unstemmed | Gluteal muscle atrophy and increased intramuscular lipid concentration are not mitigated by daily artificial gravity following 60-day head-down tilt bed rest |
| title_short | Gluteal muscle atrophy and increased intramuscular lipid concentration are not mitigated by daily artificial gravity following 60-day head-down tilt bed rest |
| title_sort | gluteal muscle atrophy and increased intramuscular lipid concentration are not mitigated by daily artificial gravity following 60 day head down tilt bed rest |
| work_keys_str_mv | AT tranv glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT demartinoe glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT hidesj glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT cableg glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT elliottjm glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT hoggarthm glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT zangej glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT lindsayk glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT debused glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT winnarda glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT beardd glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT cookja glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT salomonise glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT webert glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT scottj glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT hodgespw glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest AT caplann glutealmuscleatrophyandincreasedintramuscularlipidconcentrationarenotmitigatedbydailyartificialgravityfollowing60dayheaddowntiltbedrest |