Biochemistry: Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis

Biochemistry: Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis

Translesion synthesis (TLS) is the major pathway by which mammalian cells replicate across DNA lesions. Upon DNA damage, ubiquitination of proliferating cell nuclear antigen (PCNA) induces bypass of the lesion by directing the replication machinery into the TLS pathway. Yet, how this modification is...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Bienko, M, Green, C, Crosetto, N, Rudolf, F, Zapart, G, Coull, B, Kannouche, P, Wider, G, Peter, M, Lehmann, A, Hofmann, K, Dikic, I
Format:	Journal article
Sprache:	English
Veröffentlicht:	2005

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