MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells
The MEF2 proteins are involved in regulation of many muscle specific genes. Although MEF2 RNAs encoding the MEF2A and MEF2D isoforms are ubiquitously expressed, the presence of MEF2 proteins In nonmuscle cell types has been controversial. Here we use a well-characterised antibody in conjunction with...
| Main Authors: | , , , |
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| Format: | Journal article |
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Oxford University Press
1995
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| _version_ | 1797088358689669120 |
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| author | Dodou, E Sparrow, D Mohun, T Treisman, R |
| author_facet | Dodou, E Sparrow, D Mohun, T Treisman, R |
| author_sort | Dodou, E |
| collection | OXFORD |
| description | The MEF2 proteins are involved in regulation of many muscle specific genes. Although MEF2 RNAs encoding the MEF2A and MEF2D isoforms are ubiquitously expressed, the presence of MEF2 proteins In nonmuscle cell types has been controversial. Here we use a well-characterised antibody in conjunction with DNA binding studies to provide evidence that members of the MEF2 family are widely expressed in the nuclei of cultured cells and are competent to bind DNA. The data show that non-muscle MEF2 complexes contain MEF2A, and that another MEF2 protein, probably MEF2D, is also present. These results suggest that MEF2 proteins fulfil functions in addition to musclespecific gene expression. |
| first_indexed | 2024-03-07T02:48:54Z |
| format | Journal article |
| id | oxford-uuid:acfef17d-482f-440e-a850-dc258a95b67f |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:48:54Z |
| publishDate | 1995 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:acfef17d-482f-440e-a850-dc258a95b67f2022-03-27T03:32:31ZMEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cellsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:acfef17d-482f-440e-a850-dc258a95b67fSymplectic Elements at OxfordOxford University Press1995Dodou, ESparrow, DMohun, TTreisman, RThe MEF2 proteins are involved in regulation of many muscle specific genes. Although MEF2 RNAs encoding the MEF2A and MEF2D isoforms are ubiquitously expressed, the presence of MEF2 proteins In nonmuscle cell types has been controversial. Here we use a well-characterised antibody in conjunction with DNA binding studies to provide evidence that members of the MEF2 family are widely expressed in the nuclei of cultured cells and are competent to bind DNA. The data show that non-muscle MEF2 complexes contain MEF2A, and that another MEF2 protein, probably MEF2D, is also present. These results suggest that MEF2 proteins fulfil functions in addition to musclespecific gene expression. |
| spellingShingle | Dodou, E Sparrow, D Mohun, T Treisman, R MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells |
| title | MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells |
| title_full | MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells |
| title_fullStr | MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells |
| title_full_unstemmed | MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells |
| title_short | MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells |
| title_sort | mef2 proteins including mef2a are expressed in both muscle and non muscle cells |
| work_keys_str_mv | AT dodoue mef2proteinsincludingmef2aareexpressedinbothmuscleandnonmusclecells AT sparrowd mef2proteinsincludingmef2aareexpressedinbothmuscleandnonmusclecells AT mohunt mef2proteinsincludingmef2aareexpressedinbothmuscleandnonmusclecells AT treismanr mef2proteinsincludingmef2aareexpressedinbothmuscleandnonmusclecells |