Antimalarial dosing regimens and drug resistance.
The contribution of underdosing to antimalarial treatment failure has been underappreciated. Most recommended dosage regimens are based on studies in non-pregnant adult patients. Young children and pregnant women, who bear the heaviest malaria burden, have the highest treatment failure rates. This h...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1826290753450541056 |
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| author | Barnes, K Watkins, WM White, N |
| author_facet | Barnes, K Watkins, WM White, N |
| author_sort | Barnes, K |
| collection | OXFORD |
| description | The contribution of underdosing to antimalarial treatment failure has been underappreciated. Most recommended dosage regimens are based on studies in non-pregnant adult patients. Young children and pregnant women, who bear the heaviest malaria burden, have the highest treatment failure rates. This has been attributed previously to lower immunity, although blood concentrations of many antimalarial drugs are significantly lower in pregnant women and young children than in non-pregnant adults. Nevertheless, there have been no studies of higher dosages. Sub-therapeutic concentrations will certainly contribute to poorer responses to treatment and will fuel the emergence and spread of antimalarial drug resistance. There is an urgent need for studies to optimise antimalarial dosage regimens in infants, young children and pregnant women, both to improve cure rates and to prolong the useful therapeutic lives of antimalarial drugs. |
| first_indexed | 2024-03-07T02:49:01Z |
| format | Journal article |
| id | oxford-uuid:ad06588b-e585-4d51-b4db-e6288ba1b092 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:49:01Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:ad06588b-e585-4d51-b4db-e6288ba1b0922022-03-27T03:32:47ZAntimalarial dosing regimens and drug resistance.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ad06588b-e585-4d51-b4db-e6288ba1b092EnglishSymplectic Elements at Oxford2008Barnes, KWatkins, WMWhite, NThe contribution of underdosing to antimalarial treatment failure has been underappreciated. Most recommended dosage regimens are based on studies in non-pregnant adult patients. Young children and pregnant women, who bear the heaviest malaria burden, have the highest treatment failure rates. This has been attributed previously to lower immunity, although blood concentrations of many antimalarial drugs are significantly lower in pregnant women and young children than in non-pregnant adults. Nevertheless, there have been no studies of higher dosages. Sub-therapeutic concentrations will certainly contribute to poorer responses to treatment and will fuel the emergence and spread of antimalarial drug resistance. There is an urgent need for studies to optimise antimalarial dosage regimens in infants, young children and pregnant women, both to improve cure rates and to prolong the useful therapeutic lives of antimalarial drugs. |
| spellingShingle | Barnes, K Watkins, WM White, N Antimalarial dosing regimens and drug resistance. |
| title | Antimalarial dosing regimens and drug resistance. |
| title_full | Antimalarial dosing regimens and drug resistance. |
| title_fullStr | Antimalarial dosing regimens and drug resistance. |
| title_full_unstemmed | Antimalarial dosing regimens and drug resistance. |
| title_short | Antimalarial dosing regimens and drug resistance. |
| title_sort | antimalarial dosing regimens and drug resistance |
| work_keys_str_mv | AT barnesk antimalarialdosingregimensanddrugresistance AT watkinswm antimalarialdosingregimensanddrugresistance AT whiten antimalarialdosingregimensanddrugresistance |