Stem-loop 1 of the U1 snRNP plays a critical role in the suppression of HIV-1 polyadenylation.
The inactivity or occlusion of the HIV-1 poly(A) signal when in the 5' long terminal repeat (LTR) has been mechanistically investigated. First we show that neither the homologous HIV-1 promoter nor the close proximity of this RNA processing signal to the transcript initiation site is required f...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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